{"doi":"10.1101/2020.06.05.136531","title":"Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation","abstract":"Abstract While it is widely accepted that motor sequence learning (MSL) is supported by a prefrontal-mediated interaction between hippocampal and striatal networks, it remains unknown whether the functional responses of these networks can be modulated in humans with targeted experimental interventions. The present proof- of-concept study employed a comprehensive multimodal neuroimaging approach, including functional magnetic resonance (MR) imaging and MR spectroscopy, to investigate whether individually-tailored theta-burst stimulation of the dorsolateral prefrontal cortex can modulate responses in the hippocampus and striatum during motor learning. Our results indicate that stimulation influenced task-related connectivity patterns within hippocampo-frontal and striatal networks. Stimulation also altered the relationship between the levels of gamma-aminobutyric acid (GABA) in the stimulated prefrontal cortex and learning-related changes in both activity and connectivity in fronto-striato-hippocampal networks. This study provides the first experimental evidence that brain stimulation can alter motor learning-related functional responses in the striatum and hippocampus.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":123746,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":466009,"name":"Bradley R. King","orcid":"0000-0002-3010-8755","position":1,"is_corresponding":false},{"id":466013,"name":"Nina Dolfen","orcid":"0000-0003-1637-9548","position":2,"is_corresponding":false},{"id":567192,"name":"Menno P. Veldman","orcid":"0000-0003-1892-6664","position":3,"is_corresponding":false},{"id":458988,"name":"Kimberly L. Chan","orcid":"0000-0002-3091-2073","position":4,"is_corresponding":false},{"id":254883,"name":"Nicolaas A.J. Puts","orcid":"0000-0003-1024-1927","position":5,"is_corresponding":false},{"id":238015,"name":"Richard A.E. Edden","orcid":"0000-0002-0671-7374","position":6,"is_corresponding":false},{"id":567193,"name":"Marco Davare","orcid":"0000-0002-4670-0251","position":7,"is_corresponding":false},{"id":459008,"name":"Stephan P. Swinnen","orcid":"0000-0001-7173-435X","position":8,"is_corresponding":false},{"id":466017,"name":"Dante Mantini","orcid":"0000-0001-6485-5559","position":9,"is_corresponding":false},{"id":567194,"name":"Edwin M. Robertson","orcid":"0000-0003-2248-5902","position":10,"is_corresponding":false},{"id":466018,"name":"Geneviève Albouy","orcid":"0000-0002-5437-023X","position":11,"is_corresponding":false},{"id":567191,"name":"Mareike A. Gann","orcid":"0000-0001-5433-2965","position":0,"is_corresponding":true}],"reference_count":122,"raw_metadata":null,"created_at":"2026-07-18T23:15:03.403566Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}