{"doi":"10.1101/2020.06.04.135046","title":"Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research","abstract":"Abstract The National Center for Advancing Translational Sciences (NCATS) has developed an online open science platform – named the NCATS OpenData Portal (ODP) – for quickly and freely sharing complete NCATS translational datasets via an open-access, user-friendly interface. This paper describes the establishment of the ODP, initially deployed during the COVID-19 crisis, and provides a detailed analysis of COVID-19 drug repurposing screening datasets that served as the first large-scale use case for the platform. Over 10,000 compounds were tested across 17 quantitative high-throughput assays, covering a wide spectrum of the SARS-CoV-2 life cycle. In total, over 87,000 concentration-response curves and 426,000 data points were made publicly available on ODP in near real-time, enabling immediate access to complete datasets. The resource is flexible in accommodating various types and structures of data, and it has already expanded since its launch to host additional datasets for COVID-19, other viruses of pandemic potential, and beyond. The OpenData Portal has been designed as a scalable platform for real-time data sharing across drug discovery campaigns, regardless of disease area, with the overarching goal of accelerating discovery at NCATS, the NIH, and the greater scientific community.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":118337,"datarank":3.2716186855370966,"base_score":4.6913478822291435,"endowment":4.6913478822291435,"self_citation_contribution":0.7037021823343717,"citation_network_contribution":2.567916503202725,"self_endowment_contribution":0.7037021823343717,"citer_contribution":2.567916503202725,"corpus_percentile":93.223485727547,"corpus_rank":877,"citation_count":108,"citer_count":67,"citers_with_citation_signal":62,"citers_with_endowment":62,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5217,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":551256,"name":"Tongan Zhao","orcid":null,"position":1,"is_corresponding":false},{"id":268257,"name":"Richard T. Eastman","orcid":"0000-0003-3580-380X","position":3,"is_corresponding":false},{"id":267852,"name":"Xin Hu","orcid":"0000-0003-1164-5130","position":4,"is_corresponding":false},{"id":550312,"name":"Ke Wang","orcid":"0000-0001-7058-7853","position":5,"is_corresponding":false},{"id":551257,"name":"Mark Backus","orcid":null,"position":6,"is_corresponding":false},{"id":228430,"name":"Bolormaa Baljinnyam","orcid":"0000-0001-9548-4965","position":7,"is_corresponding":false},{"id":239788,"name":"Lu Chen","orcid":"0000-0003-0765-6662","position":8,"is_corresponding":false},{"id":550313,"name":"Tara Eicher","orcid":"0000-0003-1809-4458","position":9,"is_corresponding":false},{"id":228425,"name":"Marc Ferrer","orcid":"0000-0003-4569-9137","position":10,"is_corresponding":false},{"id":267851,"name":"Ying Fu","orcid":"0000-0002-3805-1028","position":11,"is_corresponding":false},{"id":249035,"name":"Kirill Gorshkov","orcid":"0000-0002-4652-8818","position":12,"is_corresponding":false},{"id":550314,"name":"Quinlin Hanson","orcid":"0000-0001-6033-8415","position":14,"is_corresponding":false},{"id":550315,"name":"Hui Guo","orcid":"0000-0002-4288-8058","position":17,"is_corresponding":false},{"id":225305,"name":"Sam Michael","orcid":"0000-0002-1070-6563","position":19,"is_corresponding":false},{"id":268258,"name":"Zina Itkin","orcid":"0000-0003-1686-1326","position":20,"is_corresponding":false},{"id":550316,"name":"Stephen C. Kales","orcid":"0000-0002-8702-5766","position":21,"is_corresponding":false},{"id":287620,"name":"Carleen Klumpp‐Thomas","orcid":"0000-0002-6646-6132","position":22,"is_corresponding":false},{"id":313660,"name":"Emily M. Lee","orcid":"0000-0001-8451-978X","position":23,"is_corresponding":false},{"id":551258,"name":"Tim Mierzwa","orcid":null,"position":25,"is_corresponding":false},{"id":551259,"name":"Amit Viraktamath","orcid":null,"position":26,"is_corresponding":false},{"id":550317,"name":"Andrew Patt","orcid":"0000-0002-6373-9545","position":27,"is_corresponding":false},{"id":227989,"name":"Miao Xu","orcid":"0000-0001-9968-733X","position":28,"is_corresponding":false},{"id":227990,"name":"Manisha Pradhan","orcid":"0000-0002-8710-0148","position":29,"is_corresponding":false},{"id":267850,"name":"Alex Renn","orcid":"0000-0001-6320-9459","position":30,"is_corresponding":false},{"id":234733,"name":"Paul Shinn","orcid":null,"position":31,"is_corresponding":false},{"id":268298,"name":"Jonathan H. Shrimp","orcid":"0000-0001-9872-942X","position":32,"is_corresponding":false},{"id":37894,"name":"Ewy A. Mathé","orcid":"0000-0003-4491-8107","position":33,"is_corresponding":false},{"id":255126,"name":"Matthew D. Hall","orcid":"0000-0002-5073-442X","position":35,"is_corresponding":false},{"id":339280,"name":"Kelli M. Wilson","orcid":"0000-0003-2636-2766","position":36,"is_corresponding":false},{"id":12541,"name":"Alexey Zakharov","orcid":"0000-0003-2466-1711","position":38,"is_corresponding":false},{"id":550318,"name":"Wei Zhu","orcid":"0000-0002-8200-9230","position":39,"is_corresponding":false},{"id":227992,"name":"Wei Zheng","orcid":"0000-0003-1034-0757","position":40,"is_corresponding":false},{"id":228423,"name":"Anton Simeonov","orcid":"0000-0002-4523-9977","position":41,"is_corresponding":false},{"id":249037,"name":"Donald C. Lo","orcid":"0009-0005-0369-5789","position":44,"is_corresponding":false},{"id":239789,"name":"Min Shen","orcid":"0000-0002-8218-0433","position":45,"is_corresponding":false},{"id":317762,"name":"Kyle R. Brimacombe","orcid":"0000-0002-9629-1417","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T23:13:58.531532Z","pmid":"32511420","pmcid":"PMC7276055","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}