{"doi":"10.1101/2020.06.03.130724","title":"Group II metabotropic glutamate receptors modulate sound evoked and spontaneous activity in the mouse inferior colliculus","abstract":"Abstract Little is known about the functions of group II metabotropic glutamate receptors (mGluRs2/3) in the inferior colliculus (IC)—a midbrain structure that is a major integration region of the central auditory system. We investigated how these receptors modulate sound-evoked and spontaneous firing in the mouse IC in vivo . We first performed immunostaining and tested hearing thresholds to validate VGAT-ChR2 transgenic mice on a mixed CBA/CaJ x C57BL/6J genetic background. Transgenic animals allowed for optogenetic cell type identification. Extracellular single neuron recordings were obtained before and after pharmacological mGluR2/3 activation. We observed increased sound-evoked firing—as assessed by the rate-level functions—in a subset of both GABAergic and non-GABAergic IC neurons following mGluR2/3 pharmacological activation. These neurons also displayed elevated spontaneous excitability and were distributed throughout the IC area tested, suggesting a widespread mGluR2/3 distribution in the mouse IC.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":126874,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":329806,"name":"Nichole L. Beebe","orcid":"0000-0003-3692-7986","position":1,"is_corresponding":false},{"id":533068,"name":"Jesse W. Young","orcid":"0000-0001-5358-9339","position":2,"is_corresponding":false},{"id":533069,"name":"Sharad J. Shanbhag","orcid":"0000-0002-4153-5656","position":3,"is_corresponding":false},{"id":329807,"name":"Brett R. Schofield","orcid":"0000-0002-0875-7759","position":4,"is_corresponding":false},{"id":533070,"name":"Alexander V. Galazyuk","orcid":"0000-0003-2765-9430","position":5,"is_corresponding":false},{"id":533067,"name":"Inga Kristaponyte","orcid":"0000-0003-2820-4235","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":null,"created_at":"2026-07-18T23:15:27.226519Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}