{"doi":"10.1101/2020.06.01.127795","title":"Tension promotes kinetochore-microtubule release in response to Aurora B activity","abstract":"Abstract Aurora B kinase regulates kinetochore-microtubule interactions to ensure accurate chromosome segregation in cell division. Tension provides a signal to discriminate attachment errors from bi-oriented kinetochores with sisters correctly attached to opposite spindle poles. Current models focus on tension as an input to locally regulate Aurora B activity. Here we show that the outcome of Aurora B activity depends on tension. Using an optogenetic approach to manipulate Aurora B at individual kinetochores, we find that kinase activity promotes microtubule release when tension is high. Conversely, when tension is low, Aurora B activity promotes depolymerization of kinetochore-microtubule bundles while maintaining attachment. We propose that tension is a signal inducing distinct error-correction mechanisms, with release or depolymerization advantageous for typical errors characterized by high or low tension, respectively.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":126738,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":382619,"name":"Fioranna Renda","orcid":"0000-0003-4788-7617","position":1,"is_corresponding":false},{"id":270403,"name":"Huaiying Zhang","orcid":"0000-0002-1784-2664","position":2,"is_corresponding":false},{"id":514420,"name":"Alper Gokden","orcid":"0000-0002-9659-7352","position":3,"is_corresponding":false},{"id":536716,"name":"Daniel Z. Wu","orcid":"0000-0001-6869-6532","position":4,"is_corresponding":false},{"id":239972,"name":"David M. Chenoweth","orcid":"0000-0002-0819-4669","position":5,"is_corresponding":false},{"id":382622,"name":"Alexey Khodjakov","orcid":"0000-0002-3056-3707","position":6,"is_corresponding":false},{"id":270406,"name":"Michael A. Lampson","orcid":"0000-0002-2825-1894","position":7,"is_corresponding":false},{"id":574647,"name":"Geng-Yuan Chen","orcid":"0000-0002-0103-4494","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:15:27.226519Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}