{"doi":"10.1101/2020.05.28.122242","title":"Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks","abstract":"Abstract Parallel information processing is a salient feature of complex nervous systems. For example, the medial and lateral hippocampal networks (MHN and LHN) preferentially process spatial- and object-related information, respectively. However, the mechanisms underlying parallel network assembly during development remain largely unknown. Here, we show that complementary expression of cell-surface molecules Teneurin-3 (Ten3) and Latrophilin-2 (Lphn2) in the MHN and LHN, respectively, guides the precise assembly of both the MHN and LHN. Viral-genetic perturbations in vivo demonstrate that Ten3+ axons are repelled by target-derived Lphn2, revealing that Lphn2/Ten3-mediated repulsion and Ten3/Ten3-mediated attraction cooperate to control precise target selection of MHN axons. In the LHN, Lphn2+ axons are confined to Lphn2+ targets via repulsion from Ten3+ targets. Our findings demonstrate that assembly of parallel hippocampal networks follows a ‘Ten3→Ten3, Lphn2→Lphn2’ rule instructed by reciprocal repulsions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":120601,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267313,"name":"Jan H. Lui","orcid":"0000-0003-1646-3424","position":1,"is_corresponding":false},{"id":558599,"name":"Ellen C. Gingrich","orcid":"0000-0002-8626-6226","position":2,"is_corresponding":false},{"id":242237,"name":"Chuanyun Xu","orcid":"0009-0002-1138-871X","position":3,"is_corresponding":false},{"id":267316,"name":"Mark J. Wagner","orcid":"0000-0003-1816-6407","position":4,"is_corresponding":false},{"id":510090,"name":"Yuanyuan Liu","orcid":"0000-0001-9865-1378","position":5,"is_corresponding":false},{"id":87787,"name":"Zhigang He","orcid":"0000-0001-6080-6880","position":6,"is_corresponding":false},{"id":11049,"name":"Stephen R. Quake","orcid":"0000-0002-1613-0809","position":7,"is_corresponding":false},{"id":242246,"name":"Liqun Luo","orcid":"0000-0001-5467-9264","position":8,"is_corresponding":false},{"id":558598,"name":"Daniel T. Pederick","orcid":"0000-0003-1870-9475","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-18T23:14:38.147936Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}