{"doi":"10.1101/2020.05.28.121533","title":"Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies","abstract":"Summary Neutralizing antibody responses to coronaviruses focus on the trimeric spike, with most against the receptor-binding domain (RBD). Here we characterized polyclonal IgGs and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their degree of focus on RBD epitopes, recognition of SARS-CoV, MERS-CoV, and mild coronaviruses, and how avidity effects contributed to increased binding/neutralization of IgGs over Fabs. Electron microscopy reconstructions of polyclonal plasma Fab-spike complexes showed recognition of both S1 A and RBD epitopes. A 3.4Å cryo-EM structure of a neutralizing monoclonal Fab-S complex revealed an epitope that blocks ACE2 receptor-binding on “up” RBDs. Modeling suggested that IgGs targeting these sites have different potentials for inter-spike crosslinking on viruses and would not be greatly affected by identified SARS-CoV-2 spike mutations. These studies structurally define a recurrent anti-SARS-CoV-2 antibody class derived from VH3-53/VH3-66 and similarity to a SARS-CoV VH3-30 antibody, providing criteria for evaluating vaccine-elicited antibodies.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":118335,"datarank":0.7050720548688626,"base_score":4.700480365792417,"endowment":4.700480365792417,"self_citation_contribution":0.7050720548688626,"citation_network_contribution":0.0,"self_endowment_contribution":0.7050720548688626,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":109,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104736,"name":"Anthony P. West","orcid":"0000-0003-4213-5184","position":1,"is_corresponding":false},{"id":16998,"name":"Kathryn E. Huey‐Tubman","orcid":"0000-0002-4683-8138","position":2,"is_corresponding":false},{"id":107613,"name":"Magnus A. G. Hoffmann","orcid":"0000-0003-4923-9568","position":3,"is_corresponding":false},{"id":105100,"name":"Naima G. Sharaf","orcid":"0000-0002-3662-9228","position":4,"is_corresponding":false},{"id":104735,"name":"Pauline R. Hoffman","orcid":"0000-0002-9260-3356","position":5,"is_corresponding":false},{"id":104734,"name":"Nicholas Koranda","orcid":"0009-0005-4082-7170","position":6,"is_corresponding":false},{"id":105098,"name":"Harry B. Gristick","orcid":"0000-0002-1957-2821","position":7,"is_corresponding":false},{"id":104704,"name":"Christian Gaebler","orcid":"0000-0001-7295-8128","position":8,"is_corresponding":false},{"id":16973,"name":"Frauke Muecksch","orcid":"0000-0002-0132-5101","position":9,"is_corresponding":false},{"id":104705,"name":"Julio C. C. Lorenzi","orcid":"0000-0003-2492-3961","position":10,"is_corresponding":false},{"id":104710,"name":"Shlomo Finkin","orcid":"0000-0003-4474-2658","position":11,"is_corresponding":false},{"id":104711,"name":"Thomas Hägglöf","orcid":"0000-0002-7751-0928","position":12,"is_corresponding":false},{"id":104714,"name":"Arlene Hurley","orcid":"0000-0003-0575-0233","position":13,"is_corresponding":false},{"id":104715,"name":"Katrina G. Millard","orcid":"0000-0003-2247-3178","position":14,"is_corresponding":false},{"id":16974,"name":"Yiska Weisblum","orcid":"0000-0002-9249-1745","position":15,"is_corresponding":false},{"id":104730,"name":"Fabian Schmidt","orcid":"0000-0001-7731-6685","position":16,"is_corresponding":false},{"id":104738,"name":"Théodora Hatziioannou","orcid":"0000-0002-7889-0766","position":17,"is_corresponding":false},{"id":16992,"name":"Paul D. Bieniasz","orcid":"0000-0002-2368-3719","position":18,"is_corresponding":false},{"id":104739,"name":"Marina Caskey","orcid":"0000-0003-1727-8693","position":19,"is_corresponding":false},{"id":104703,"name":"Davide F. Robbiani","orcid":"0000-0001-7379-3484","position":20,"is_corresponding":false},{"id":104187,"name":"Michel C. Nussenzweig","orcid":"0000-0003-0592-8564","position":21,"is_corresponding":false},{"id":17000,"name":"Pamela J. Björkman","orcid":"0000-0002-2277-3990","position":22,"is_corresponding":false},{"id":16968,"name":"Christopher O. Barnes","orcid":"0000-0003-2754-5951","position":0,"is_corresponding":true}],"reference_count":111,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:58.531532Z","pmid":"32577645","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}