{"doi":"10.1101/2020.05.27.20114090","title":"Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series","abstract":"Abstract Background Following early implementation of public health measures, San Francisco has experienced a slow rise and a low peak level of coronavirus disease 2019 (COVID-19) cases and deaths. Methods and Findings We included all patients with COVID-19 pneumonia admitted to the intensive care unit (ICU) at the safety net hospital for San Francisco through April 8, 2020. Each patient had ≥15 days of follow-up. Among 26 patients, the median age was 54 years (interquartile range, 43 to 62), 65% were men, and 77% were Latinx. Mechanical ventilation was initiated for 11 (42%) patients within 24 hours of ICU admission and 20 patients (77%) overall. The median duration of mechanical ventilation was 13.5 days (interquartile range, 5 to 20). Patients were managed with lung protective ventilation (tidal volume ≤8 ml/kg of ideal body weight and plateau pressure ≤30 cmH 2 O on 98% and 78% of ventilator days, respectively). Prone positioning was used for 13 of 20 (65%) ventilated patients for a median of 5 days (interquartile range, 2 to 10). Seventeen (65%) patients were discharged home, 1 (4%) was discharged to nursing home, 3 (12%) were discharged from the ICU, and 2 (8%) remain intubated in the ICU at the time of this report. Three (12%) patients have died. Conclusions Good outcomes were achieved in critically ill patients with COVID-19 by using standard therapies for acute respiratory distress syndrome (ARDS) such as lung protective ventilation and prone positioning. Ensuring hospitals can deliver sustained high-quality and evidence-based critical care to patients with ARDS should remain a priority.","journal":"medRxiv","year":2020,"id":120296,"datarank":1.3288310769257932,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.9560950794575931,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.9560950794575931,"corpus_percentile":84.4975632397308,"corpus_rank":2005,"citation_count":11,"citer_count":11,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":557410,"name":"Narges Alipanah","orcid":"0000-0002-8381-5701","position":1,"is_corresponding":false},{"id":557411,"name":"Rebecca Crowder","orcid":"0000-0001-6374-3088","position":2,"is_corresponding":false},{"id":378253,"name":"Christina Yoon","orcid":"0000-0003-0865-4108","position":3,"is_corresponding":false},{"id":557412,"name":"Richard Wang","orcid":"0000-0003-3442-0559","position":4,"is_corresponding":false},{"id":232428,"name":"Neeta Thakur","orcid":"0000-0001-6126-6601","position":5,"is_corresponding":false},{"id":558202,"name":"Kristin Slown","orcid":null,"position":6,"is_corresponding":false},{"id":315613,"name":"Priya B. Shete","orcid":"0000-0002-0279-8170","position":7,"is_corresponding":false},{"id":558203,"name":"Martin Rofael","orcid":null,"position":8,"is_corresponding":false},{"id":387484,"name":"John Metcalfe","orcid":"0000-0002-2279-7036","position":9,"is_corresponding":false},{"id":558204,"name":"Cindy Merrifield","orcid":null,"position":10,"is_corresponding":false},{"id":255287,"name":"Carina Marquez","orcid":"0000-0002-7622-6562","position":11,"is_corresponding":false},{"id":557413,"name":"Katherine Malcolm","orcid":"0000-0002-1293-0809","position":12,"is_corresponding":false},{"id":42889,"name":"Michael S. Lipnick","orcid":"0000-0001-9978-1465","position":13,"is_corresponding":false},{"id":255284,"name":"Vivek Jain","orcid":"0000-0002-7835-1447","position":14,"is_corresponding":false},{"id":558205,"name":"Antonio Gomez","orcid":null,"position":15,"is_corresponding":false},{"id":558206,"name":"Gregory Burns","orcid":null,"position":16,"is_corresponding":false},{"id":255286,"name":"Lillian B. Brown","orcid":"0000-0003-1809-3762","position":17,"is_corresponding":false},{"id":387482,"name":"Christopher A. Berger","orcid":"0000-0002-0034-7544","position":18,"is_corresponding":false},{"id":557414,"name":"Vincent C. Auyeung","orcid":"0000-0001-6273-1595","position":19,"is_corresponding":false},{"id":315466,"name":"Adithya Cattamanchi","orcid":"0000-0002-6553-2601","position":20,"is_corresponding":false},{"id":409499,"name":"Carolyn M. Hendrickson","orcid":"0000-0003-4662-2385","position":21,"is_corresponding":false},{"id":517309,"name":"Sky Vanderburg","orcid":"0000-0001-8855-3555","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:14:33.640077Z","pmid":"32511538","pmcid":"PMC7273306","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}