{"doi":"10.1101/2020.05.27.119305","title":"R-type voltage-gated Ca <sup>2+</sup> channels mediate A-type K <sup>+</sup> current regulation of synaptic input in hippocampal dendrites","abstract":"SUMMARY The transient K + current (I A ) carried by pore forming Kv4.2 subunits regulates the propagation of synaptic input, dendritic excitability, and synaptic plasticity in CA1 pyramidal neuron dendrites of the hippocampus. We report that the Ca 2+ channel subunit Cav2.3 regulates I A in this cell type. We first identified Cav2.3 as a Kv4.2 interacting protein in a proteomic screen and we confirmed Cav2.3-Kv4.2 complex association using multiple techniques. Functionally, Cav2.3 Ca 2+ -entry increases Kv4.2-mediated whole-cell current due to an increase in Kv4.2 surface expression. Using pharmacology and Cav2.3 knockout mice, Cav2.3 was found to promote whole-cell I A and the increasing gradient of I A in the apical dendrite distal to the neuronal soma. Furthermore, the loss of Cav2.3 function leads to enhancement of synaptic currents and spine Ca 2+ influx. These results present Cav2.3 and Kv4.2 as integral constituents of an ion channel complex that impacts synaptic function in the hippocampus.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":132331,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350827,"name":"Jakob J. Gutzmann","orcid":"0000-0002-4538-1391","position":1,"is_corresponding":false},{"id":352766,"name":"Lin Lin","orcid":"0000-0003-4702-7190","position":2,"is_corresponding":false},{"id":588440,"name":"Jiahua Hu","orcid":null,"position":3,"is_corresponding":false},{"id":277236,"name":"Ronald S. Petralia","orcid":"0000-0003-4423-8355","position":4,"is_corresponding":false},{"id":277237,"name":"Yaxian Wang","orcid":"0000-0001-5854-9352","position":5,"is_corresponding":false},{"id":350830,"name":"Dax A. Hoffman","orcid":"0000-0001-6999-2157","position":6,"is_corresponding":false},{"id":583357,"name":"Jonathan G. Murphy","orcid":"0000-0001-6485-5727","position":0,"is_corresponding":true}],"reference_count":127,"raw_metadata":null,"created_at":"2026-07-18T23:16:10.654971Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}