{"doi":"10.1101/2020.05.23.112235","title":"Bepridil is potent against SARS-CoV-2 In Vitro","abstract":"ABSTRACT Guided by a computational docking analysis, about 30 FDA/EMA-approved small molecule medicines were characterized on their inhibition of the SARS-CoV-2 main protease (M Pro ). Of these tested small molecule medicines, six displayed an IC 50 value in inhibiting M Pro below 100 μM. Three medicines pimozide, ebastine, and bepridil are basic small molecules. Their uses in COVID-19 patients potentiate dual functions by both raising endosomal pH to slow SARS-CoV-2 entry into the human cell host and inhibiting M Pro in infected cells. A live virus-based microneutralization assay showed that bepridil inhibited cytopathogenic effect induced by SARS-CoV-2 in Vero E6 cells completely at and dose-dependently below 5 μM and in A549 cells completely at and dose-dependently below 6.25 μM. Therefore, the current study urges serious considerations of using bepridil in COVID-19 clinical tests.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119053,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":264693,"name":"Kai S. Yang","orcid":"0000-0002-1890-4169","position":1,"is_corresponding":false},{"id":265654,"name":"Kaci C. Kratch","orcid":null,"position":2,"is_corresponding":false},{"id":255555,"name":"Aleksandra Drelich","orcid":"0000-0002-0201-5017","position":3,"is_corresponding":false},{"id":553387,"name":"Chia-Chuan Cho","orcid":null,"position":4,"is_corresponding":false},{"id":552808,"name":"Drake M. Mellott","orcid":"0000-0002-8043-8170","position":5,"is_corresponding":false},{"id":264703,"name":"Shiqing Xu","orcid":"0000-0001-6260-9290","position":6,"is_corresponding":false},{"id":218437,"name":"Chien‐Te K. Tseng","orcid":"0000-0001-5726-9834","position":7,"is_corresponding":false},{"id":264704,"name":"Wenshe Ray Liu","orcid":"0000-0002-7078-6534","position":8,"is_corresponding":false},{"id":264697,"name":"Erol C. Vatansever","orcid":"0000-0002-8392-5791","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:14:03.409507Z","pmid":"32511370","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}