{"doi":"10.1101/2020.05.19.104588","title":"Spontaneous restoration of functional β-cell mass in obese SM/J mice","abstract":"Abstract Maintenance of functional β-cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β-cell populations to thrive or fail in the context of obesity are unknown. High fat-fed SM/J mice spontaneously transition from hyperglycemic-obese to normoglycemic-obese with age, providing a unique opportunity to study β-cell adaptation. Here, we characterize insulin homeostasis, islet morphology, and β-cell function during SM/J’s diabetic remission. As they resolve hyperglycemia, obese SM/J mice dramatically increase circulating and pancreatic insulin levels while improving insulin sensitivity. Immunostaining of pancreatic sections reveals that obese SM/J mice selectively increase β-cell mass but not α-cell mass. Obese SM/J mice do not show elevated β-cell mitotic index, but rather elevated α-cell mitotic index. Functional assessment of isolated islets reveals that obese SM/J mice increase glucose stimulated insulin secretion, decrease basal insulin secretion, and increase islet insulin content. These results establish that β-cell mass expansion and improved β-cell function underlie the resolution of hyperglycemia, indicating that obese SM/J mice are a valuable tool for exploring how functional β-cell mass can be recovered in the context of obesity.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":126715,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":55087,"name":"Caryn Carson","orcid":"0000-0003-2091-3109","position":1,"is_corresponding":false},{"id":275081,"name":"Celine L. St. Pierre","orcid":"0000-0001-5465-6601","position":2,"is_corresponding":false},{"id":376499,"name":"Juan F Macias-Velasco","orcid":"0000-0003-2827-4647","position":3,"is_corresponding":false},{"id":281270,"name":"Jing W. Hughes","orcid":"0000-0003-4397-8175","position":4,"is_corresponding":false},{"id":574603,"name":"Marcus Kunzmann","orcid":"0000-0001-7261-7278","position":5,"is_corresponding":false},{"id":377719,"name":"Heather K. Schmidt","orcid":null,"position":6,"is_corresponding":false},{"id":377720,"name":"Jessica P. Wayhart","orcid":null,"position":7,"is_corresponding":false},{"id":24492,"name":"Heather A. Lawson","orcid":"0000-0002-3550-5485","position":8,"is_corresponding":false},{"id":376501,"name":"Mario A Miranda","orcid":"0000-0001-7382-2521","position":0,"is_corresponding":true}],"reference_count":92,"raw_metadata":null,"created_at":"2026-07-18T23:15:27.226519Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}