{"doi":"10.1101/2020.05.15.098616","title":"SARS-CoV2 (COVID-19) Structural/Evolution Dynamicome: Insights into functional evolution and human genomics","abstract":"The SARS-CoV-2 pandemic, starting in 2019, has challenged the speed at which labs perform science, ranging from discoveries of the viral composition to handling health outcomes in humans. The small ~30kb single-stranded RNA genome of Coronaviruses makes them adept at cross species spread and drift, increasing their probability to cause pandemics. However, this small genome also allows for a robust understanding of all proteins coded by the virus. We employed protein modeling, molecular dynamic simulations, evolutionary mapping, and 3D printing to gain a full proteome and dynamicome understanding of SARS-CoV-2. The Viral Integrated Structural Evolution Dynamic Database (VIStEDD) has been established (prokoplab.com/vistedd), opening future discoveries and educational usage. In this paper, we highlight VIStEDD usage for nsp6, Nucleocapsid (N), and Spike (S) surface glycoprotein. For both nsp6 and N we reveal highly conserved surface amino acids that likely drive protein-protein interactions. In characterizing viral S protein, we have developed a quantitative dynamics cross correlation matrix insight into interaction with the ACE2/SLC6A19 dimer complex. From this quantitative matrix, we elucidated 47 potential functional missense variants from population genomic databases within ACE2/SLC6A19/TMPRSS2, warranting genomic enrichment analyses in SARS-CoV-2 patients. Moreover, these variants have ultralow frequency, but can exist as hemizygous in males for ACE2, which falls on the X-chromosome. Two noncoding variants (rs4646118 and rs143185769) found in ~9% of African descent individuals for ACE2 may regulate expression and be related to increased susceptibility of African Americans to SARS-CoV-2. This powerful database of SARS-CoV-2 can aid in research progress in the ongoing pandemic.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":120290,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9219,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":558191,"name":"Jacob Charron","orcid":null,"position":1,"is_corresponding":false},{"id":426801,"name":"Cynthia L. 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Faber","orcid":null,"position":6,"is_corresponding":false},{"id":558194,"name":"Austin Frisch","orcid":null,"position":7,"is_corresponding":false},{"id":558195,"name":"Eric Lind","orcid":null,"position":8,"is_corresponding":false},{"id":557394,"name":"Jacob Bauss","orcid":"0000-0001-8823-3690","position":9,"is_corresponding":false},{"id":426798,"name":"Xiaopeng Li","orcid":"0000-0001-7926-193X","position":10,"is_corresponding":false},{"id":557395,"name":"Olivia Sirpilla","orcid":"0000-0002-0634-407X","position":11,"is_corresponding":false},{"id":557396,"name":"Xavier Soehnlen","orcid":"0000-0003-1054-8064","position":12,"is_corresponding":false},{"id":445020,"name":"Adam Underwood","orcid":"0000-0001-8232-4129","position":13,"is_corresponding":false},{"id":292328,"name":"David A. Hinds","orcid":"0000-0002-4911-803X","position":14,"is_corresponding":false},{"id":426802,"name":"Michèle Morris","orcid":"0000-0003-2529-4597","position":15,"is_corresponding":false},{"id":32963,"name":"Neil E. Lamb","orcid":null,"position":16,"is_corresponding":false},{"id":34789,"name":"Joseph A. Carcillo","orcid":"0000-0001-8920-4330","position":17,"is_corresponding":false},{"id":426804,"name":"Caleb Bupp","orcid":"0000-0003-4255-0396","position":18,"is_corresponding":false},{"id":557397,"name":"Bruce D. Uhal","orcid":"0000-0002-5201-432X","position":19,"is_corresponding":false},{"id":394895,"name":"Surender Rajasekaran","orcid":"0000-0002-4430-006X","position":20,"is_corresponding":false},{"id":394893,"name":"Jeremy W. Prokop","orcid":"0000-0002-1818-9695","position":21,"is_corresponding":false},{"id":557392,"name":"Ruchir Gupta","orcid":"0000-0002-2346-6001","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T23:14:33.640077Z","pmid":"32511397","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}