{"doi":"10.1101/2020.05.15.096719","title":"IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity","abstract":"COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity or as a therapeutic has yet been developed to SARS-CoV-2. In this study we discover and characterize a cross-reactive human IgA monoclonal antibody, MAb362. MAb362 binds to both SARS-CoV and SARS-CoV-2 spike proteins and competitively blocks hACE2 receptor binding, by completely overlapping the hACE2 structural binding epitope. Furthermore, MAb362 IgA neutralizes both pseudotyped SARS-CoV and SARS-CoV-2 in human epithelial cells expressing hACE2. SARS-CoV-2 specific IgA antibodies, such as MAb362, may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119118,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553483,"name":"Qi Li","orcid":"0000-0003-4435-6220","position":1,"is_corresponding":false},{"id":249882,"name":"Shurong Hou","orcid":"0000-0001-5143-0797","position":2,"is_corresponding":false},{"id":249883,"name":"Zachary A. Schiller","orcid":"0000-0002-4185-2416","position":3,"is_corresponding":false},{"id":249885,"name":"Aaron Wallace","orcid":"0000-0003-0876-661X","position":4,"is_corresponding":false},{"id":252758,"name":"Alla Amcheslavsky","orcid":null,"position":5,"is_corresponding":false},{"id":249886,"name":"Neşe Kurt Yılmaz","orcid":"0000-0002-5036-676X","position":6,"is_corresponding":false},{"id":249889,"name":"Jacqueline R. Toomey","orcid":"0000-0002-3629-1896","position":7,"is_corresponding":false},{"id":249890,"name":"Ryan M. Schneider","orcid":"0000-0001-7122-1079","position":8,"is_corresponding":false},{"id":249891,"name":"Brianna J. Close","orcid":"0000-0002-0563-1464","position":9,"is_corresponding":false},{"id":249892,"name":"Da‐Yuan Chen","orcid":"0000-0002-1957-3330","position":10,"is_corresponding":false},{"id":249893,"name":"Hasahn L. Conway","orcid":"0000-0001-7328-3521","position":11,"is_corresponding":false},{"id":232300,"name":"Mohsan Saeed","orcid":"0000-0001-8505-7054","position":12,"is_corresponding":false},{"id":249894,"name":"Lisa A. Cavacini","orcid":"0000-0003-1417-8339","position":13,"is_corresponding":false},{"id":252763,"name":"Mark S. Klempner","orcid":null,"position":14,"is_corresponding":false},{"id":249895,"name":"Celia A. Schiffer","orcid":"0000-0003-2270-6613","position":15,"is_corresponding":false},{"id":553484,"name":"Yang Wang","orcid":"0000-0002-6527-864X","position":16,"is_corresponding":false},{"id":249880,"name":"Monir Ejemel","orcid":"0000-0001-9155-5914","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":"32511396","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}