{"doi":"10.1101/2020.05.13.20100925","title":"Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19","abstract":"The SARS-CoV-2 is responsible for the pandemic COVID-19 in infected individuals, who can either exhibit mild symptoms or progress towards a life-threatening acute respiratory distress syndrome (ARDS). It is known that exacerbated inflammation and dysregulated immune responses involving T and myeloid cells occur in COVID-19 patients with severe clinical progression. However, the differential contribution of specific subsets of dendritic cells and monocytes to ARDS is still poorly understood. In addition, the role of CD8+ T cells present in the lung of COVID-19 patients and relevant for viral control has not been characterized. With the aim to improve the knowledge in this area, we developed a cross-sectional study, in which we have studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood of COVID-19 patients with different clinical severity in comparison with healthy control individuals. Furthermore, these subpopulations and their association with antiviral effector CD8+ T cell subsets were also characterized in lung infiltrates from critical COVID-19 patients. Collectively, our results suggest that inflammatory transitional and non-classical monocytes preferentially migrate from blood to lungs in patients with severe COVID-19. CD1c+ conventional dendritic cells also followed this pattern, whereas CD141+ conventional and CD123hi plasmacytoid dendritic cells were depleted from blood but were absent in the lungs. Thus, this study increases the knowledge on the pathogenesis of COVID-19 disease and could be useful for the design of therapeutic strategies to fight SARS-CoV-2 infection.","journal":"medRxiv","year":2020,"id":118487,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244376,"name":"Pedro Landete","orcid":"0000-0002-9631-9408","position":1,"is_corresponding":false},{"id":244377,"name":"Beatriz Aldave","orcid":"0000-0003-2316-5791","position":2,"is_corresponding":false},{"id":248064,"name":"Santiago Sánchez‐Alonso","orcid":null,"position":3,"is_corresponding":false},{"id":551463,"name":"Ana Sánchez Azofra","orcid":null,"position":4,"is_corresponding":false},{"id":244379,"name":"Ana Marcos‐Jiménez","orcid":"0000-0002-7606-3580","position":5,"is_corresponding":false},{"id":244380,"name":"Elena Ávalos","orcid":"0000-0002-9988-4605","position":6,"is_corresponding":false},{"id":244381,"name":"Ana Alcaraz‐Serna","orcid":"0000-0002-9452-6788","position":7,"is_corresponding":false},{"id":244382,"name":"Ignacio de los Santos","orcid":"0000-0001-7073-5211","position":8,"is_corresponding":false},{"id":244383,"name":"Tamara Mateu‐Albero","orcid":"0000-0003-2084-9629","position":9,"is_corresponding":false},{"id":248065,"name":"Laura Esparcia","orcid":null,"position":10,"is_corresponding":false},{"id":244384,"name":"Celia López‐Sanz","orcid":"0000-0001-7203-0290","position":11,"is_corresponding":false},{"id":244385,"name":"Pedro Martínez‐Fleta","orcid":"0000-0001-6107-0262","position":12,"is_corresponding":false},{"id":244386,"name":"Ligia Gabrie","orcid":"0000-0002-9363-1914","position":13,"is_corresponding":false},{"id":248066,"name":"Luciana del Campo Guerola","orcid":null,"position":14,"is_corresponding":false},{"id":244388,"name":"Marı́a J. Calzada","orcid":"0000-0001-8615-960X","position":15,"is_corresponding":false},{"id":244389,"name":"Isidoro González‐Álvaro","orcid":"0000-0001-9614-5199","position":16,"is_corresponding":false},{"id":244390,"name":"Arántzazu Alfranca","orcid":"0000-0002-3732-5816","position":17,"is_corresponding":false},{"id":244391,"name":"Francisco Sánchez‐Madrid","orcid":"0000-0001-5303-0762","position":18,"is_corresponding":false},{"id":244392,"name":"Cecilia Muñoz‐Calleja","orcid":"0000-0003-4085-3115","position":19,"is_corresponding":false},{"id":48711,"name":"Joan B. 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