{"doi":"10.1101/2020.05.06.081745","title":"A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues","abstract":"Abstract Light-sheet microscopy has emerged as the preferred means for high-throughput volumetric imaging of cleared tissues. However, there is a need for a user-friendly system that can address imaging applications with varied requirements in terms of resolution (mesoscopic to sub-micrometer), sample geometry (size, shape, and number), and compatibility with tissue-clearing protocols and sample holders of various refractive indices. 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