{"doi":"10.1101/2020.04.30.071282","title":"Decoupling transcription factor expression and activity enables dimmer-switch gene regulation","abstract":"Abstract Our mechanistic understanding of how gene regulatory networks can achieve complex biological responses is limited. We find that the galactose-responsive pathway in S. cerevisiae has a complex behavior - the decision to induce is controlled independently from the induction level, resembling a mechanical dimmer-switch. Surprisingly, this behavior is not achieved directly through chromatin regulation or combinatorial control at galactose-responsive promoters. Instead, this behavior is achieved by hierarchical regulation of the expression and catalytic activity of a single transcription factor. This genetic motif allows evolution to independently act on both properties, providing a means to tune both resource allocation strategies in dynamic multi-input environments on both physiological and evolutionary time-scales. Hierarchical regulation is ubiquitous and thus dimmer-switch regulation is likely a key feature of many biological systems.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":123634,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":552250,"name":"Jue Wang","orcid":"0000-0002-1139-6640","position":1,"is_corresponding":false},{"id":566968,"name":"Ishay Ben-Zion","orcid":"0000-0003-4423-7870","position":2,"is_corresponding":false},{"id":566969,"name":"Julius Palme","orcid":"0000-0001-5897-1334","position":3,"is_corresponding":false},{"id":566970,"name":"Ang Li","orcid":"0000-0003-3933-588X","position":4,"is_corresponding":false},{"id":561649,"name":"Yonatan Savir","orcid":"0000-0002-5345-8491","position":5,"is_corresponding":false},{"id":528758,"name":"Michael Springer","orcid":"0000-0002-3970-6380","position":6,"is_corresponding":false},{"id":448995,"name":"Chiara Ricci-Tam","orcid":"0000-0002-6549-1838","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:15:03.403566Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}