{"doi":"10.1101/2020.04.22.050385","title":"Convergent evolution of p38/MAPK activation in hormone resistant prostate cancer mediates pro-survival, immune evasive, and metastatic phenotypes","abstract":"Summary Adaptation of cancer cells to targeted therapy follows ecological paradigms observed in natural populations that encounter resource depletion and changing environments, including activation of pro-survival mechanisms, migration to new locations, and escape of predation. We identified the p38 MAPK pathway as a common molecular driver of these three responses during the adaptation to hormone therapy resistance in prostate cancer. The p38 pathway is activated in therapy-resistant cells and mechanistically drives these three convergent responses through sustained AR activity, enhanced invasion and metastasis, and immune evasion. Targeting p38 signaling may represent a new therapeutic strategy to treat men with metastatic, hormone therapy-resistant prostate cancer.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119885,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":556029,"name":"Santosh Gupta","orcid":"0000-0003-1132-4812","position":1,"is_corresponding":false},{"id":556030,"name":"Jared Eng","orcid":"0000-0002-8609-0574","position":2,"is_corresponding":false},{"id":556733,"name":"Gabor Kemeny","orcid":null,"position":3,"is_corresponding":false},{"id":556031,"name":"Bhairavy Puviindran","orcid":"0000-0002-8827-0050","position":4,"is_corresponding":false},{"id":492232,"name":"Wen‐Chi Foo","orcid":"0000-0003-0631-9613","position":5,"is_corresponding":false},{"id":72592,"name":"Lorin Crawford","orcid":"0000-0003-0178-8242","position":6,"is_corresponding":false},{"id":556734,"name":"R. Garland Almquist","orcid":null,"position":7,"is_corresponding":false},{"id":556735,"name":"Daniella Runyambo","orcid":null,"position":8,"is_corresponding":false},{"id":339315,"name":"Beatrice C. Thomas","orcid":"0000-0002-7982-5640","position":9,"is_corresponding":false},{"id":75055,"name":"Maya U. Sheth","orcid":"0000-0003-1466-8899","position":10,"is_corresponding":false},{"id":556032,"name":"Anika Agarwal","orcid":"0000-0002-8820-7297","position":11,"is_corresponding":false},{"id":556033,"name":"Mariaelena Pierobon","orcid":"0000-0003-2084-1029","position":12,"is_corresponding":false},{"id":406272,"name":"Emanuel F. Petricoin","orcid":"0000-0001-8787-5990","position":13,"is_corresponding":false},{"id":65837,"name":"David L. Corcoran","orcid":"0000-0001-7460-9247","position":14,"is_corresponding":false},{"id":32930,"name":"Jennifer A. Freedman","orcid":"0000-0001-6771-4161","position":15,"is_corresponding":false},{"id":353552,"name":"Steven R. Patierno","orcid":"0000-0003-0636-2128","position":16,"is_corresponding":false},{"id":278282,"name":"Tian Zhang","orcid":"0000-0001-8914-3531","position":17,"is_corresponding":false},{"id":59323,"name":"Simon G. Gregory","orcid":"0000-0002-7805-1743","position":18,"is_corresponding":false},{"id":351736,"name":"Zoi E. Sychev","orcid":"0000-0002-9830-5245","position":19,"is_corresponding":false},{"id":351743,"name":"Justin M. Drake","orcid":"0000-0002-8329-7748","position":20,"is_corresponding":false},{"id":260281,"name":"Andrew J. Armstrong","orcid":"0000-0001-7012-1754","position":21,"is_corresponding":false},{"id":339312,"name":"Jason A. Somarelli","orcid":"0000-0003-1510-9343","position":22,"is_corresponding":false},{"id":340760,"name":"Kathryn E. Ware","orcid":null,"position":0,"is_corresponding":true}],"reference_count":90,"raw_metadata":null,"created_at":"2026-07-18T23:14:13.002105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}