{"doi":"10.1101/2020.04.08.031336","title":"Reversed sex-biased mutation rates for indels and base substitutions in\n                  <i>Drosophila melanogaster</i>","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Sex biases in mutation rates may affect the rate of adaptive evolution. In many species, males have higher mutation rates than females when single nucleotide variants (SNVs) are considered. In contrast, indel mutations in humans and chimpanzees are female-biased. In\n                  <jats:italic>Drosophila melanogaster</jats:italic>\n                  , direct estimates of mutation rates did not uncover sex differences, but a recent analysis suggested the presence of male-biased SNVs mutations. Here we study the sex-specific mutation processes using mutation accumulation data from mismatch-repair deficient\n                  <jats:italic>D. melanogaster</jats:italic>\n                  . We find that sex differences in flies are similar to the ones observed in humans: a higher mutation rate for SNVs in males and a higher indel rate in females. These results have major implications for the study of neutral variation and adaptation in\n                  <jats:italic>Drosophila</jats:italic>\n                  .\n                </jats:p>","journal":null,"year":null,"id":588251,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1227223,"name":"Claire Burny","orcid":"0000-0002-0279-3812","position":1,"is_corresponding":false},{"id":1371647,"name":"Christian Schlötterer","orcid":"0000-0003-4710-6526","position":2,"is_corresponding":false},{"id":1504891,"name":"Lauri Törmä","orcid":"0000-0002-9227-3887","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Reversed sex-biased mutation rates for indels and base substitutions in\n                  <i>Drosophila melanogaster</i>","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Sex biases in mutation rates may affect the rate of adaptive evolution. In many species, males have higher mutation rates than females when single nucleotide variants (SNVs) are considered. In contrast, indel mutations in humans and chimpanzees are female-biased. In\n                  <jats:italic>Drosophila melanogaster</jats:italic>\n                  , direct estimates of mutation rates did not uncover sex differences, but a recent analysis suggested the presence of male-biased SNVs mutations. Here we study the sex-specific mutation processes using mutation accumulation data from mismatch-repair deficient\n                  <jats:italic>D. melanogaster</jats:italic>\n                  . We find that sex differences in flies are similar to the ones observed in humans: a higher mutation rate for SNVs in males and a higher indel rate in females. These results have major implications for the study of neutral variation and adaptation in\n                  <jats:italic>Drosophila</jats:italic>\n                  .\n                </jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20725694","pmcid":null,"openalex_id":"https://openalex.org/W3015930054","authors":[],"funders":[{"funder_name":"Austrian Science Fund (FWF)","grant_id":"W 1225","title":"Vollantrag zu Population Genetics"}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2021,"count":1}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2020/04/09/2020.04.08.031336.full.pdf","host_type":"repository"},{"url":"https://doi.org/10.1101/2020.04.08.031336","host_type":"GREEN"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2020/04/09/2020.04.08.031336.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2020.04.08.031336","host_type":"publisher"},{"url":"https://dx.doi.org/10.1101/2020.04.08.031336","host_type":""},{"url":"http://dx.doi.org/10.1101/2020.04.08.031336","host_type":""}],"fields_of_study":["Evolution and Genetic Dynamics","Genetic diversity and population structure","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Indel","Drosophila melanogaster","Mutation rate","Biology","Mutation","Genetics","Mutation Accumulation","Adaptation (eye)","Drosophila (subgenus)","INDEL Mutation","Single-nucleotide polymorphism","Gene","Genotype"],"sdg_mappings":[{"sdg_number":10,"sdg_label":"10. No inequality"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-19T22:56:29.821937Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}