{"doi":"10.1101/2020.03.24.005900","title":"Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses","abstract":"Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":122020,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":495013,"name":"Minato Hirano","orcid":null,"position":1,"is_corresponding":false},{"id":494382,"name":"W. Samuel Fagg","orcid":"0000-0003-2909-1666","position":2,"is_corresponding":false},{"id":494383,"name":"Eileen T. McAnarney","orcid":"0000-0003-2337-2889","position":3,"is_corresponding":false},{"id":254584,"name":"Chao Shan","orcid":"0000-0002-3953-3782","position":4,"is_corresponding":false},{"id":105317,"name":"Xuping Xie","orcid":"0000-0003-0918-016X","position":5,"is_corresponding":false},{"id":254582,"name":"Adam Hage","orcid":"0000-0001-7668-892X","position":6,"is_corresponding":false},{"id":495014,"name":"Colette Pietzsch","orcid":null,"position":7,"is_corresponding":false},{"id":235604,"name":"Alexander Bukreyev","orcid":"0000-0002-0342-4824","position":8,"is_corresponding":false},{"id":107099,"name":"Ricardo Rajsbaum","orcid":"0000-0002-5058-5444","position":9,"is_corresponding":false},{"id":38215,"name":"Pei‐Yong Shi","orcid":"0000-0001-5553-1616","position":10,"is_corresponding":false},{"id":275709,"name":"Mark T. Bedford","orcid":"0000-0002-8899-1050","position":11,"is_corresponding":false},{"id":276957,"name":"Shelton S. Bradrick","orcid":"0000-0003-1566-9797","position":12,"is_corresponding":false},{"id":105316,"name":"Vineet D. Menachery","orcid":"0000-0001-8803-7606","position":13,"is_corresponding":false},{"id":232721,"name":"Mariano A. García-Blanco","orcid":"0000-0001-8538-1997","position":14,"is_corresponding":false},{"id":495012,"name":"K. Reddisiva Prasanth","orcid":null,"position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:14:46.979435Z","pmid":"32511318","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}