{"doi":"10.1101/2020.03.20.000869","title":"A functional non-coding RNA is produced from <i>xbp-1</i> mRNA","abstract":"Abstract The xbp-1 mRNA encodes the XBP-1 transcription factor, a critical part of the unfolded protein response. Here we report that an RNA fragment produced from xbp-1 mRNA cleavage is a biologically active non-coding RNA (ncRNA) in Caenorhabditis elegans neurons, providing the first example of ncRNA derived from mRNA cleavage. We show that the xbp-1 ncRNA is crucial for axon regeneration in vivo , and that it acts independently of the protein-coding function of the xbp-1 transcript. Structural analysis indicates that the function of the xbp-1 ncRNA depends on a single RNA stem; and this stem forms only in the cleaved xbp-1 ncRNA fragment. Disruption of this stem abolishes the non-coding but not coding function of the endogenous xbp-1 transcript. Thus, cleavage of the xbp-1 mRNA bifurcates it into a coding and a non-coding pathway; modulation of the two pathways may allow neurons to fine-tune their response to injury and other stresses. Graphic abstract","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":126408,"datarank":0.13992496354640377,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.035952886462411945,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.035952886462411945,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":39886,"name":"Jean-Denis Beaudoin","orcid":"0000-0003-4932-1668","position":1,"is_corresponding":false},{"id":382564,"name":"Carrie Ann Davison","orcid":"0000-0002-2358-207X","position":2,"is_corresponding":false},{"id":384030,"name":"Sara Guckian Kosmaczewski","orcid":null,"position":3,"is_corresponding":false},{"id":382565,"name":"Benjamin I. Meyer","orcid":"0000-0002-0970-5854","position":4,"is_corresponding":false},{"id":3244,"name":"Antonio J. Giráldez","orcid":"0000-0002-6823-137X","position":5,"is_corresponding":false},{"id":382566,"name":"Marc Hammarlund","orcid":"0000-0002-3068-068X","position":6,"is_corresponding":false},{"id":573880,"name":"Xiao Liu","orcid":"0009-0007-4780-8399","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:23.509897Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}