{"doi":"10.1101/2020.03.17.995639","title":"Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model","abstract":"Abstract A novel coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared with historical SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and mucous glands of the nasal cavity. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 can cause a COVID-19-like disease, and suggest that the severity of SARS-CoV-2 infection is intermediate between that of SARS-CoV and MERS-CoV. One Sentence Summary SARS-CoV-2 infection in macaques results in COVID-19-like disease with prolonged virus excretion from nose and throat in absence of clinical signs.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":118320,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":115,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336186,"name":"Thijs Kuiken","orcid":"0000-0001-5501-9049","position":1,"is_corresponding":false},{"id":218422,"name":"Sander Herfst","orcid":"0000-0001-9866-8903","position":2,"is_corresponding":false},{"id":130424,"name":"Theo M. Bestebroer","orcid":null,"position":3,"is_corresponding":false},{"id":227373,"name":"Mart M. Lamers","orcid":"0000-0002-1431-4022","position":4,"is_corresponding":false},{"id":227372,"name":"Dennis de Meulder","orcid":"0000-0002-3631-4189","position":5,"is_corresponding":false},{"id":550289,"name":"Geert van Amerongen","orcid":"0000-0002-5469-6029","position":6,"is_corresponding":false},{"id":247719,"name":"Judith M. A. van den Brand","orcid":"0000-0001-8420-5406","position":7,"is_corresponding":false},{"id":107142,"name":"Nisreen M.A. Okba","orcid":"0000-0002-2394-1079","position":8,"is_corresponding":false},{"id":550290,"name":"Debby Schipper","orcid":"0000-0001-6449-4765","position":9,"is_corresponding":false},{"id":550291,"name":"Peter van Run","orcid":"0000-0001-6963-4165","position":10,"is_corresponding":false},{"id":338094,"name":"Lonneke Leijten","orcid":null,"position":11,"is_corresponding":false},{"id":550292,"name":"Ernst J. Verschoor","orcid":"0000-0003-0912-2074","position":12,"is_corresponding":false},{"id":550293,"name":"Babs E. Verstrepen","orcid":"0000-0002-4666-0798","position":13,"is_corresponding":false},{"id":550294,"name":"Jan A. M. Langermans","orcid":"0000-0002-4806-4412","position":14,"is_corresponding":false},{"id":57977,"name":"Christian Drosten","orcid":"0000-0001-7923-0519","position":15,"is_corresponding":false},{"id":227374,"name":"Martje Fentener van Vlissingen","orcid":"0000-0003-2213-5910","position":16,"is_corresponding":false},{"id":227375,"name":"Ron A. M. Fouchier","orcid":"0000-0001-8095-2869","position":17,"is_corresponding":false},{"id":107148,"name":"Rik L. de Swart","orcid":"0000-0003-3599-8969","position":18,"is_corresponding":false},{"id":107146,"name":"Marion Koopmans","orcid":"0000-0002-5204-2312","position":19,"is_corresponding":false},{"id":70955,"name":"Bart L Haagmans","orcid":"0000-0001-6221-2015","position":20,"is_corresponding":false},{"id":218432,"name":"Barry Rockx","orcid":"0000-0003-2463-027X","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:13:58.531532Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}