{"doi":"10.1101/2020.03.17.989699","title":"Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells","abstract":"HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against infection 1 . However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors 2 . Antibody genes can be engineered into B cells for expression as both a functional receptor on cell surfaces and as secreted antibody 3–5 . Here, we show that HIV bnAb-engineered primary mouse B cells can be adoptively transferred and vaccinated in immunocompetent wild-type animals resulting in the expansion of durable bnAb memory and long-lived plasma cells. Somatic hypermutation after immunization indicated that engineered cells have the capacity to respond to an evolving pathogen. These results encourage further exploration of engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infection and as a contributor to a functional cure.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119282,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297046,"name":"Jenny Tuyet Tran","orcid":null,"position":1,"is_corresponding":false},{"id":296035,"name":"Alex Olson","orcid":"0000-0002-3371-3213","position":2,"is_corresponding":false},{"id":296036,"name":"Thomas Vollbrecht","orcid":"0000-0003-1151-8844","position":3,"is_corresponding":false},{"id":296038,"name":"Mariia V. Guryleva","orcid":"0009-0004-6370-7510","position":4,"is_corresponding":false},{"id":296037,"name":"Mary Tenuta","orcid":"0000-0002-0708-3932","position":5,"is_corresponding":false},{"id":297047,"name":"Roberta Fuller","orcid":null,"position":6,"is_corresponding":false},{"id":285899,"name":"Torben Schiffner","orcid":"0000-0001-6772-8870","position":7,"is_corresponding":false},{"id":296039,"name":"Justin R. Abadejos","orcid":"0000-0001-8271-627X","position":8,"is_corresponding":false},{"id":297048,"name":"Lauren Couvrette","orcid":null,"position":9,"is_corresponding":false},{"id":296040,"name":"Tanya R. Blane","orcid":"0000-0001-8132-3167","position":10,"is_corresponding":false},{"id":297049,"name":"Karen Saye","orcid":null,"position":11,"is_corresponding":false},{"id":296041,"name":"Wenjuan Li","orcid":"0000-0002-2231-7338","position":12,"is_corresponding":false},{"id":108977,"name":"Elise Landais","orcid":"0000-0002-8183-5565","position":13,"is_corresponding":false},{"id":296042,"name":"Alicia González-Martín","orcid":"0000-0002-6179-089X","position":14,"is_corresponding":false},{"id":236279,"name":"William R. Schief","orcid":"0000-0002-1120-0150","position":15,"is_corresponding":false},{"id":296043,"name":"Ben Murrell","orcid":"0000-0002-0393-4445","position":16,"is_corresponding":false},{"id":108980,"name":"Dennis R. Burton","orcid":"0000-0001-6711-9864","position":17,"is_corresponding":false},{"id":109546,"name":"David Nemazee","orcid":"0000-0002-4769-6311","position":18,"is_corresponding":false},{"id":109547,"name":"James E. Voss","orcid":"0000-0002-4777-1596","position":19,"is_corresponding":false},{"id":108972,"name":"Deli Huang","orcid":"0000-0002-6989-639X","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}