{"doi":"10.1101/2020.03.06.949131","title":"Role of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity","abstract":"Abstract Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in ∼10% of these patients is through lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data suggest a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may be relevant for other solid tumors.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119115,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259316,"name":"Anke Augspach","orcid":"0000-0002-3788-2719","position":1,"is_corresponding":false},{"id":259317,"name":"Maria Rosaria De Filippo","orcid":"0000-0001-8350-2599","position":2,"is_corresponding":false},{"id":259318,"name":"Davide Prandi","orcid":"0000-0001-9885-6074","position":3,"is_corresponding":false},{"id":261268,"name":"Phillip Thienger","orcid":null,"position":4,"is_corresponding":false},{"id":259319,"name":"Matteo Benelli","orcid":"0000-0003-1227-356X","position":5,"is_corresponding":false},{"id":261269,"name":"Victoria Cooley","orcid":null,"position":6,"is_corresponding":false},{"id":92091,"name":"Rohan Bareja","orcid":"0000-0002-0635-7743","position":7,"is_corresponding":false},{"id":259320,"name":"David Wilkes","orcid":"0000-0002-2422-1145","position":8,"is_corresponding":false},{"id":554814,"name":"Sung‐Suk Chae","orcid":null,"position":9,"is_corresponding":false},{"id":261271,"name":"Paola Cavaliere","orcid":null,"position":10,"is_corresponding":false},{"id":259321,"name":"Noah Dephoure","orcid":"0000-0001-5802-2657","position":11,"is_corresponding":false},{"id":259322,"name":"Anne‐Christine Uldry","orcid":"0000-0003-2820-0277","position":12,"is_corresponding":false},{"id":261272,"name":"Sophie Braga Lagache","orcid":null,"position":13,"is_corresponding":false},{"id":259324,"name":"Sandra Cohen","orcid":"0000-0002-0727-4245","position":14,"is_corresponding":false},{"id":261273,"name":"Muriel Jaquet","orcid":null,"position":15,"is_corresponding":false},{"id":261274,"name":"Laura P. Brandt","orcid":null,"position":16,"is_corresponding":false},{"id":259325,"name":"Mohammed Alshalalfa","orcid":"0000-0001-8405-3035","position":17,"is_corresponding":false},{"id":41062,"name":"Andrea Sboner","orcid":"0000-0001-6915-3070","position":18,"is_corresponding":false},{"id":259327,"name":"Felix Y. Feng","orcid":"0000-0002-0963-7687","position":19,"is_corresponding":false},{"id":261275,"name":"Shangqian Wang","orcid":null,"position":20,"is_corresponding":false},{"id":85728,"name":"Himisha Beltran","orcid":"0000-0003-3259-2226","position":21,"is_corresponding":false},{"id":323563,"name":"Tamara L. Lotan","orcid":"0000-0002-0494-9067","position":22,"is_corresponding":false},{"id":259328,"name":"Martin Spahn","orcid":"0000-0002-5770-9489","position":23,"is_corresponding":false},{"id":553481,"name":"Marianna Kruithof-de Julio","orcid":"0000-0002-6693-8515","position":24,"is_corresponding":false},{"id":259330,"name":"Yu Chen","orcid":"0000-0002-0171-3884","position":25,"is_corresponding":false},{"id":259331,"name":"Karla V. Ballman","orcid":"0000-0002-4492-0357","position":26,"is_corresponding":false},{"id":35285,"name":"Francesca Demichelis","orcid":"0000-0002-8266-8631","position":27,"is_corresponding":false},{"id":259332,"name":"Salvatore Piscuoglio","orcid":"0000-0003-2686-2939","position":28,"is_corresponding":false},{"id":13152,"name":"Mark A. Rubin","orcid":"0000-0002-8321-9950","position":29,"is_corresponding":false},{"id":259315,"name":"Joanna Cyrta","orcid":"0000-0002-0216-5330","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-18T23:14:08.313144Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}