{"doi":"10.1101/2020.03.04.977629","title":"TGFβ Suppresses Type 2 Immunity to Cancer","abstract":"Summary The immune system employs two distinct defense strategies against infections: pathogen elimination typified by type 1 immunity, and pathogen containment exemplified by type 2 immunity in association with tissue repair. Akin to infectious diseases, cancer progresses with cancer cell acquisition of microorganism-like behavior propagating at the expense of the host. While immunological mechanisms of cancer cell elimination are well defined, whether immune-mediated cancer cell containment can be induced is poorly understood. Here we show that ablation of transforming growth factor-β receptor II (TGFβRII) in CD4 + T cells promotes tumor tissue healing and halts cancer progression. Notably, the restorative response is dependent on the T helper 2 cytokine IL-4 fortifying vasculature organization that spares only proximal layers of cancer cells from hypoxia, nutrient starvation and death. Thus, type 2 immunity represents an effective cancer defense mechanism, and TGFβ signaling in helper T cells may be targeted for novel cancer immunotherapy.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":129100,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244688,"name":"Fengshen Kuo","orcid":"0000-0003-1797-2896","position":1,"is_corresponding":false},{"id":240587,"name":"Kristelle J. Capistrano","orcid":"0000-0003-4349-9924","position":2,"is_corresponding":false},{"id":252676,"name":"Davina Kang","orcid":null,"position":3,"is_corresponding":false},{"id":240583,"name":"Briana G. Nixon","orcid":"0000-0001-7334-9404","position":4,"is_corresponding":false},{"id":474728,"name":"Wei Shi","orcid":"0000-0001-5453-1753","position":5,"is_corresponding":false},{"id":240581,"name":"Chun Chou","orcid":"0000-0001-7147-4236","position":6,"is_corresponding":false},{"id":240580,"name":"H. Mytrang","orcid":"0000-0002-3043-3902","position":7,"is_corresponding":false},{"id":580317,"name":"Shun Li","orcid":"0000-0001-9063-2965","position":8,"is_corresponding":false},{"id":240582,"name":"Efstathios G. Stamatiades","orcid":"0000-0002-2785-9005","position":9,"is_corresponding":false},{"id":249413,"name":"Ying‐Bei Chen","orcid":"0000-0001-5207-3648","position":10,"is_corresponding":false},{"id":249414,"name":"James J. Hsieh","orcid":"0000-0003-3595-0551","position":11,"is_corresponding":false},{"id":90737,"name":"A. Ari Hakimi","orcid":"0000-0002-0930-8824","position":12,"is_corresponding":false},{"id":118806,"name":"Ichiro Taniuchi","orcid":"0000-0002-9853-9068","position":13,"is_corresponding":false},{"id":69956,"name":"Timothy A. Chan","orcid":"0000-0002-9265-0283","position":14,"is_corresponding":false},{"id":240589,"name":"Ming O. Li","orcid":"0000-0002-1383-0535","position":15,"is_corresponding":false},{"id":461679,"name":"Ming Liu","orcid":"0000-0003-4548-2683","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:45.920615Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}