{"doi":"10.1101/2020.02.26.20028399","title":"ZIKA VIRUS VERTICAL TRANSMISSION IN CHILDREN WITH CONFIRMED ANTENATAL EXPOSURE","abstract":"ABSTRACT Background In utero transmission of Zika virus (ZIKV) can lead to adverse infant outcomes, but vertical transmission rates are unknown. Methods Antenatally ZIKV-exposed children were followed prospectively since the time of the Rio de Janeiro epidemic in 2015-16. Serum and urine specimens were collected from infants from birth throughout the first year of life. Specimens were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM antibody capture Zika MAC-ELISA. Infants had neurodevelopmental evaluations, brain imaging, eye examinations, and hearing assessments. Results Over time 130 in utero ZIKV-exposed (mothers PCR+) children were tested with 407 specimens evaluated: 161 sera were tested by PCR and IgM assays, 85 urines by PCR; 84 children (65%) were positive in at least one assay. Among 94 children tested within 3 months of age, 70% were positive (39% serum PCR, 48% urine PCR, 39% IgM). After 3 months, 33% were positive by any laboratory method. Five children were intermittently PCR+ beyond 200 days of life. Concordance between IgM and PCR results was 52%, sensitivity 65%, specificity 40% (with any positive PCR result as the gold standard); IgM and serum PCR were 61% concordant; serum and urine PCR 55%. Most children (65%) were clinically normal. Positive results were seen in 29 of 45 children (64%) with abnormal findings and 55 of 85 normal children (65%), p=0·98. Earlier maternal trimester of infection was associated with positive infant laboratory results but not infant clinical disease (p=0·04). Conclusions ZIKV has a high in utero transmission rate. Laboratory confirmed infection is not necessarily associated with abnormal infant findings.","journal":"medRxiv","year":2020,"id":121990,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9635,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305512,"name":"Zilton Vasconcelos","orcid":"0000-0002-2193-2224","position":1,"is_corresponding":false},{"id":305519,"name":"Tara Kerin","orcid":"0000-0003-2655-5605","position":2,"is_corresponding":false},{"id":356757,"name":"Claudia Raja Gabaglia","orcid":"0000-0001-6786-2228","position":3,"is_corresponding":false},{"id":356758,"name":"Ieda Pereira Ribeiro","orcid":"0000-0002-0874-6072","position":4,"is_corresponding":false},{"id":356759,"name":"Myrna C. Bonaldo","orcid":"0000-0001-9899-3386","position":5,"is_corresponding":false},{"id":356760,"name":"Luana Damasceno","orcid":"0000-0003-1724-598X","position":6,"is_corresponding":false},{"id":305513,"name":"Marcos Vinícius da Silva Pone","orcid":"0000-0002-5152-2242","position":7,"is_corresponding":false},{"id":305514,"name":"Sheila Moura Pone","orcid":"0000-0002-6246-8915","position":8,"is_corresponding":false},{"id":305515,"name":"Andréa Zin","orcid":"0000-0001-7677-0034","position":9,"is_corresponding":false},{"id":356761,"name":"Irena Tsui","orcid":"0000-0001-7989-5174","position":10,"is_corresponding":false},{"id":305520,"name":"Kristina Adachi","orcid":"0000-0002-5796-2767","position":11,"is_corresponding":false},{"id":305516,"name":"José Paulo Pereira","orcid":"0000-0002-2975-9681","position":12,"is_corresponding":false},{"id":273919,"name":"Stephanie L. Gaw","orcid":"0000-0003-0891-6964","position":13,"is_corresponding":false},{"id":357681,"name":"Liege Carvalho","orcid":null,"position":14,"is_corresponding":false},{"id":356762,"name":"Denise Cotrim da Cunha","orcid":"0000-0003-1602-5504","position":15,"is_corresponding":false},{"id":356763,"name":"Letícia da Cunha Guida","orcid":"0000-0003-3543-1532","position":16,"is_corresponding":false},{"id":357682,"name":"Mirza Rocha","orcid":null,"position":17,"is_corresponding":false},{"id":357683,"name":"James D. Cherry","orcid":null,"position":18,"is_corresponding":false},{"id":357684,"name":"Lulan Wang","orcid":null,"position":19,"is_corresponding":false},{"id":357685,"name":"Saba R. Aliyari","orcid":null,"position":20,"is_corresponding":false},{"id":104315,"name":"Genhong Cheng","orcid":"0000-0002-6713-2783","position":21,"is_corresponding":false},{"id":356764,"name":"Suan‐Sin Foo","orcid":"0009-0007-8174-0893","position":22,"is_corresponding":false},{"id":356765,"name":"Weiqiang Chen","orcid":"0000-0002-8840-1823","position":23,"is_corresponding":false},{"id":107313,"name":"Jae U. Jung","orcid":"0000-0003-4559-8774","position":24,"is_corresponding":false},{"id":305990,"name":"Elizabeth B. Brickley","orcid":"0000-0003-0280-2288","position":25,"is_corresponding":false},{"id":305523,"name":"Maria Elisabeth Lopes Moreira","orcid":"0000-0002-2034-0294","position":26,"is_corresponding":false},{"id":305511,"name":"Karin Nielsen‐Saines","orcid":"0000-0002-1742-5211","position":27,"is_corresponding":false},{"id":305518,"name":"Patrícia Brasil","orcid":"0000-0001-9555-7976","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T23:14:46.979435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}