{"doi":"10.1101/2020.02.11.942532","title":"IGF-I Governs Cortical Inhibitory Synaptic Plasticity By Astrocyte Activation","abstract":"ABSTRACT Insulin-like growth factor-I (IGF-I) signaling plays key regulatory roles in multiple processes of brain physiology and pathology. While the direct effects of IGF-I in neurons have been extensively studied, the astrocyte involvement in IGF-I signaling and the consequences on synaptic plasticity and animal behavior remain unknown. Here we show that IGF-I induces the long-term depression (LTD) of inhibitory synaptic transmission in the mouse barrel cortex. This LTD requires the activation of the IGF-I receptor (IGF-IR) in astrocytes, which stimulates astrocyte Ca 2+ signaling and the release of ATP/adenosine that in turn activates A 2A adenosine receptors at presynaptic inhibitory terminals. Specific deletion of IGF-IR in cortical astrocytes (IGF-IR -/- ) impaired the behavioral performance in a whisker discrimination task. These results show novel mechanisms and functional consequences of IGF-I signaling on cortical inhibitory synaptic plasticity and animal behavior, revealing astrocytes as key elements in these processes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":121959,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":562174,"name":"Laura E. Maglio","orcid":"0000-0003-4760-5624","position":1,"is_corresponding":false},{"id":562175,"name":"Jonathan Zegarra-Valdivia","orcid":"0000-0003-0497-5270","position":2,"is_corresponding":false},{"id":562176,"name":"Jaime Pignatelli","orcid":"0000-0002-8431-2241","position":3,"is_corresponding":false},{"id":295527,"name":"Ana M. Fernández","orcid":"0000-0001-5160-3854","position":4,"is_corresponding":false},{"id":562679,"name":"Laura Martinez‐Rachadell","orcid":null,"position":5,"is_corresponding":false},{"id":562177,"name":"Jansen Fernandes","orcid":"0000-0002-6177-5884","position":6,"is_corresponding":false},{"id":562178,"name":"Ángel Núñez","orcid":"0000-0002-8013-4812","position":7,"is_corresponding":false},{"id":232010,"name":"Alfonso Araque","orcid":"0000-0003-3840-1144","position":8,"is_corresponding":false},{"id":562179,"name":"Ignacio Torres‐Alemán","orcid":"0000-0001-8107-7947","position":9,"is_corresponding":false},{"id":562180,"name":"David Fernández de Sevilla","orcid":"0000-0001-6344-0773","position":10,"is_corresponding":false},{"id":562173,"name":"Jose Antonio Noriega‐Prieto","orcid":"0000-0002-3086-8746","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-18T23:14:46.979435Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}