{"doi":"10.1101/2020.02.07.938589","title":"The haemodynamics of the human placenta in utero","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  We have used MRI to provide important new insights into the function of the human placenta\n                  <jats:italic>in utero</jats:italic>\n                  . We have measured slow net flow and high net oxygenation in the placenta\n                  <jats:italic>in vivo</jats:italic>\n                  , which are consistent with efficient delivery of oxygen from mother to fetus. Our experimental evidence substantiates previous hypotheses on the effects of spiral artery remodelling\n                  <jats:italic>in utero</jats:italic>\n                  , and also indicates rapid venous drainage from the placenta, which is important since the outflow has been largely neglected in the past. Furthermore, beyond Braxton Hicks contractions, which involve the entire uterus, we have identified a new physiological phenomenon, the ‘\n                  <jats:italic>utero-placental pump</jats:italic>\n                  ’, by which the placenta and underlying uterine wall contract independently of the rest of the uterus, expelling maternal blood from the intervillous space.\n                </jats:p>","journal":null,"year":null,"id":621492,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":315064,"name":"George Hutchinson","orcid":"0000-0002-8069-9821","position":1,"is_corresponding":false},{"id":316167,"name":"Simon Shah","orcid":null,"position":2,"is_corresponding":false},{"id":1604902,"name":"Nia W. Jones","orcid":null,"position":3,"is_corresponding":false},{"id":605711,"name":"Chris Bradley","orcid":"0000-0003-4042-867X","position":4,"is_corresponding":false},{"id":315067,"name":"Lopa Leach","orcid":"0000-0002-9266-6808","position":5,"is_corresponding":false},{"id":11551,"name":"Craig Platt","orcid":null,"position":6,"is_corresponding":false},{"id":315068,"name":"Richard Bowtell","orcid":"0000-0001-8656-412X","position":7,"is_corresponding":false},{"id":1604903,"name":"Penny A. Gowland","orcid":null,"position":8,"is_corresponding":false},{"id":315063,"name":"Neele Dellschaft","orcid":"0000-0001-5483-1684","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The haemodynamics of the human placenta in utero","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  We have used MRI to provide important new insights into the function of the human placenta\n                  <jats:italic>in utero</jats:italic>\n                  . We have measured slow net flow and high net oxygenation in the placenta\n                  <jats:italic>in vivo</jats:italic>\n                  , which are consistent with efficient delivery of oxygen from mother to fetus. Our experimental evidence substantiates previous hypotheses on the effects of spiral artery remodelling\n                  <jats:italic>in utero</jats:italic>\n                  , and also indicates rapid venous drainage from the placenta, which is important since the outflow has been largely neglected in the past. Furthermore, beyond Braxton Hicks contractions, which involve the entire uterus, we have identified a new physiological phenomenon, the ‘\n                  <jats:italic>utero-placental pump</jats:italic>\n                  ’, by which the placenta and underlying uterine wall contract independently of the rest of the uterus, expelling maternal blood from the intervillous space.\n                </jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W3004882390","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"1U01HD087202-01","title":"Structure and function of the placenta from implantation to delivery: a next generation MRI approach"},{"funder_name":"UK Research and Innovation","grant_id":"MC_PC_13072","title":"UoNottingham Confidence in Concept2013"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2024,"count":1}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2020/04/21/2020.02.07.938589.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2020/04/21/2020.02.07.938589.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2020.02.07.938589","host_type":"publisher"},{"url":"https://doi.org/10.1101/2020.02.07.938589","host_type":"repository"},{"url":"https://doi.org/10.1371/journal.pbio.3000676","host_type":""},{"url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000676&type=printable","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/32463837","host_type":""},{"url":"http://dx.doi.org/10.1371/journal.pbio.3000676","host_type":""},{"url":"https://doaj.org/article/74ba38c72719431eb5b3954820924e09","host_type":""},{"url":"https://dx.doi.org/10.1101/2020.02.07.938589","host_type":""},{"url":"https://dx.doi.org/10.1371/journal.pbio.3000676","host_type":""},{"url":"http://dx.doi.org/10.1101/2020.02.07.938589","host_type":""}],"fields_of_study":["Pregnancy and preeclampsia studies","Maternal and fetal healthcare","Congenital Diaphragmatic Hernia Studies","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Intervillous space","Placenta","In utero","Uterus","Spiral artery","Fetus","Hemodynamics","Medicine","Anatomy","Pregnancy","Biology","Internal medicine","Adult","QH301-705.5","Oxygen","Young Adult","Pre-Eclampsia","Case-Control Studies","Humans","Female","Placental Circulation","Biology (General)","Blood Flow Velocity","Magnetic Resonance Angiography","Research Article"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T14:48:08.711670Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}