{"doi":"10.1101/2020.02.06.936989","title":"Non-linear Computation Between Neighboring Dendritic Hotspots in Rat CA1 Hippocampal Interneurons","abstract":"ABSTRACT Dendritic hotspots have been shown to play a determining role as local activity foci during sensory information coding and memory formation in cortical neurons in vivo . Here we aim to reveal the characteristics of co-activating more dendritic hotspots themselves within a dynamic time window. Using electrical stimulation and patterned two-photon uncaging for the coincident activation of two neighboring dendritic hotspots in rat hippocampal CA1 interneurons, the evoked local dendritic Ca 2+ and the associated excitatory postsynaptic potentials (EPSPs) summed supralinearly. Between active hotspots, supralinearity was present in a relatively broad temporal (∼10 ms) and spatial (∼30 µm) window, mediated by NMDA receptors. Though at larger inter-hotspot distances (>30 µm) supralinear summation of EPSPs was replaced by sublinear integration, the summation of dendritic Ca 2+ responses remained supralinear. The inter-hotspot integration represents a novel signal integration state, extending the interaction distance between dendritic inputs, and allowing long-range coincidence detection.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":128842,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":579544,"name":"Zoltán Szadai","orcid":"0000-0002-6286-4686","position":1,"is_corresponding":false},{"id":580104,"name":"Klaudia Spitzer","orcid":null,"position":2,"is_corresponding":false},{"id":579545,"name":"Gergely Katona","orcid":"0000-0002-4173-0355","position":3,"is_corresponding":false},{"id":580105,"name":"Éva Csordás Tóth","orcid":null,"position":4,"is_corresponding":false},{"id":579546,"name":"Gábor Tamás","orcid":"0000-0002-7905-6001","position":5,"is_corresponding":false},{"id":251861,"name":"Balázs Rózsa","orcid":"0000-0003-1427-7003","position":6,"is_corresponding":false},{"id":579543,"name":"Attila Kaszás","orcid":"0000-0002-2019-3722","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:15:42.522809Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}