{"doi":"10.1101/2020.01.27.20018671","title":"Seasonally Variant Gene Expression in Full-Term Human Placenta","abstract":"ABSTRACT Seasonal exposures influence human health and development. The placenta, as a mediator of the maternal and fetal systems and a regulator of development, is an ideal tissue to understand the biological pathways underlying relationships between season of birth and later life health outcomes. Here, we conducted a transcriptome-wide association study of season of birth in full-term human placental tissue to evaluate whether the placenta may be influenced by seasonal cues. Of the analyzed transcripts, 583 displayed differential expression between summer and winter births (FDR q<0.05); among these, BHLHE40, MIR210HG , and HILPDA had increased expression among winter births (Bonferroni p<0.05). Enrichment analyses of the seasonally variant genes between summer and winter births indicated over-representation of transcription factors HIF1A, VDR, and CLOCK, among others, and of GO term pathways related to ribosomal activity and infection. Additionally, a cosinor analysis found rhythmic expression for approximately 11.9% of all 17,664 analyzed placental transcripts. These results suggest that the placenta responds to seasonal cues and add to the growing body of evidence that the placenta acts as a peripheral clock, which may provide a molecular explanation for the extensive associations between season of birth and health outcomes.","journal":"medRxiv","year":2020,"id":126225,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9387,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":407080,"name":"Elizabeth M. Kennedy","orcid":"0000-0003-0074-2840","position":1,"is_corresponding":false},{"id":354348,"name":"Todd M. Everson","orcid":"0000-0003-2732-4550","position":2,"is_corresponding":false},{"id":340251,"name":"Maya A. Deyssenroth","orcid":"0000-0003-2913-2392","position":3,"is_corresponding":false},{"id":354349,"name":"Amber Burt","orcid":"0000-0003-1813-6726","position":4,"is_corresponding":false},{"id":266345,"name":"Ke Hao","orcid":"0000-0002-1815-9197","position":5,"is_corresponding":false},{"id":340252,"name":"Jia Chen","orcid":"0000-0001-6597-8577","position":6,"is_corresponding":false},{"id":288916,"name":"Machelle T. Pardue","orcid":"0000-0001-8738-6839","position":7,"is_corresponding":false},{"id":328176,"name":"Carmen J. Marsit","orcid":"0000-0003-4566-150X","position":8,"is_corresponding":false},{"id":574219,"name":"Danielle Clarkson-Townsend","orcid":null,"position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:23.509897Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}