{"doi":"10.1101/2020.01.08.898346","title":"CD4 <sup>+</sup> follicular helper-like T cells are key players in anti-tumor immunity","abstract":"ABSTRACT To determine the nature of CD4 + T cells that provide ‘help’ for generating robust anti-tumor CD8 + cytotoxic T cell (CTL) responses, we profiled the transcriptomes of patient-matched CD4 + and CD8 + T cells present in the tumor micro-environment (TME) and analyzed them jointly using integrated weighted gene correlation network analysis. We found the follicular helper T cell (T FH ) program in CD4 + T cells was strongly associated with proliferation and tissue-residency in CD8 + CTLs. Single-cell analysis demonstrated the presence of T FH -like cells and features linked to cytotoxic function and their provision of CD8 + T cell ‘help’. Tumor-infiltrating T FH -like cells expressed PD-1 and were enriched in tumors following checkpoint blockade, suggesting that they may respond to anti-PD-1 therapy. Adoptive transfer or induction of T FH cells in mouse models resulted in augmented CD8 + CTL responses and impairment of tumor growth, indicating an important role of T FH -like CD4 + T cells in anti-tumor immunity.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":119972,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":556815,"name":"AP Ganesan","orcid":null,"position":1,"is_corresponding":false},{"id":27484,"name":"Bharat Panwar","orcid":"0000-0002-4227-9615","position":2,"is_corresponding":false},{"id":110381,"name":"Simon Eschweiler","orcid":"0000-0002-6379-8588","position":3,"is_corresponding":false},{"id":349821,"name":"Christopher J. Hanley","orcid":"0000-0003-3816-7220","position":4,"is_corresponding":false},{"id":269136,"name":"Ariel Madrigal","orcid":null,"position":5,"is_corresponding":false},{"id":7247,"name":"Ciro Ramírez-Suástegui","orcid":"0000-0001-8126-710X","position":6,"is_corresponding":false},{"id":277905,"name":"Andrew Z. Wang","orcid":"0000-0002-9781-4494","position":7,"is_corresponding":false},{"id":247019,"name":"James Clarke","orcid":"0009-0001-8803-4728","position":8,"is_corresponding":false},{"id":248664,"name":"Oliver Wood","orcid":null,"position":9,"is_corresponding":false},{"id":247017,"name":"Eva M. Garrido‐Martín","orcid":"0000-0002-8094-2668","position":10,"is_corresponding":false},{"id":556816,"name":"S. J. T. Chee","orcid":null,"position":11,"is_corresponding":false},{"id":110383,"name":"Grégory Seumois","orcid":"0000-0002-8164-6852","position":12,"is_corresponding":false},{"id":104937,"name":"Simon Bélanger","orcid":"0000-0002-9172-8376","position":13,"is_corresponding":false},{"id":247021,"name":"Aiman Alzetani","orcid":"0000-0002-3373-6714","position":14,"is_corresponding":false},{"id":556817,"name":"E. Woo","orcid":null,"position":15,"is_corresponding":false},{"id":556818,"name":"PS Friedmann","orcid":null,"position":16,"is_corresponding":false},{"id":103780,"name":"Shane Crotty","orcid":"0000-0002-6484-6262","position":17,"is_corresponding":false},{"id":556819,"name":"GJ Thomas","orcid":null,"position":18,"is_corresponding":false},{"id":247025,"name":"Tilman Sánchez-Elsner","orcid":"0000-0003-1915-2410","position":19,"is_corresponding":false},{"id":45041,"name":"Ferhat Ay","orcid":"0000-0002-0708-6914","position":20,"is_corresponding":false},{"id":110384,"name":"Christian H. Ottensmeier","orcid":"0000-0003-3619-1657","position":21,"is_corresponding":false},{"id":110385,"name":"Pandurangan Vijayanand","orcid":"0000-0001-7067-9723","position":22,"is_corresponding":false},{"id":556236,"name":"Divya Singh","orcid":"0000-0002-2961-735X","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-18T23:14:13.002105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}