{"doi":"10.1101/2020.01.07.897553","title":"Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons","abstract":"Abstract Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Super susceptibility to tuberculosis 1 (Sst1) locus in mice confers resistance to diverse bacterial infections. Here we provide evidence that Sp140 is a gene encoded within the Sst1 locus that represses type I IFN transcription during bacterial infections. We generated Sp140 -/- mice and find they are susceptible to infection by Legionella pneumophila and Mycobacterium tuberculosis. Susceptibility of Sp140 -/- mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor (Ifnar -/- ). Our results implicate Sp140 as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections. Impact Statement Repression of type I interferons by SP140 is essential for resistance to Legionella pneumophila and Mycobacterium tuberculosis .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":120084,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":556929,"name":"Kristen C. Witt","orcid":"0000-0001-8744-9457","position":1,"is_corresponding":false},{"id":556930,"name":"Dmitri I. Kotov","orcid":"0000-0001-7843-1503","position":2,"is_corresponding":false},{"id":556931,"name":"Shally R. Margolis","orcid":"0000-0003-3537-1672","position":3,"is_corresponding":false},{"id":418990,"name":"Alexander Louie","orcid":null,"position":4,"is_corresponding":false},{"id":556932,"name":"Victoria Chevée","orcid":"0009-0002-5936-0302","position":5,"is_corresponding":false},{"id":253220,"name":"Katherine J. Chen","orcid":null,"position":6,"is_corresponding":false},{"id":556933,"name":"Moritz M. Gaidt","orcid":"0000-0002-8009-294X","position":7,"is_corresponding":false},{"id":558010,"name":"Harmandeep S Dhaliwal","orcid":null,"position":8,"is_corresponding":false},{"id":253221,"name":"Angus Y. Lee","orcid":null,"position":9,"is_corresponding":false},{"id":249428,"name":"Stephen L. Nishimura","orcid":"0000-0003-2312-4113","position":10,"is_corresponding":false},{"id":363607,"name":"Dario S. Zamboni","orcid":"0000-0002-7856-7512","position":11,"is_corresponding":false},{"id":351323,"name":"Igor Kramnik","orcid":"0000-0001-6511-9246","position":12,"is_corresponding":false},{"id":351114,"name":"Daniel A. Portnoy","orcid":"0000-0003-1218-2799","position":13,"is_corresponding":false},{"id":498111,"name":"K. Heran Darwin","orcid":"0000-0002-5043-7548","position":14,"is_corresponding":false},{"id":251793,"name":"Russell E. Vance","orcid":"0000-0002-6686-3912","position":15,"is_corresponding":false},{"id":556928,"name":"Daisy X. Ji","orcid":"0000-0002-9148-3620","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:14:33.640077Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}