{"doi":"10.1101/2020.01.03.893305","title":"The immediate early gene <i>Arc</i> is not required for hippocampal long-term potentiation","abstract":"ABSTRACT The immediate early gene Arc is critical for maintenance of long-term memory. How Arc mediates this process remains unclear, but it has been proposed to sustain Hebbian synaptic potentiation, which is a key component of memory encoding. This form of plasticity is modelled experimentally by induction of long-term potentiation (LTP), which increases Arc mRNA and protein expression. However, mechanistic data implicates Arc in the endocytosis of AMPA-type glutamate receptors and the weakening of synapses. Here, we took a comprehensive approach to determine if Arc is necessary for hippocampal LTP. We find that Arc is not required for LTP maintenance and must regulate memory storage through alternative mechanisms.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":124510,"datarank":0.21449391458534856,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.049702071285132085,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.049702071285132085,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":569153,"name":"Lenora J. Volk","orcid":"0000-0002-9074-4091","position":1,"is_corresponding":false},{"id":499012,"name":"Samuel F. Cooke","orcid":"0000-0002-4876-6502","position":2,"is_corresponding":false},{"id":261781,"name":"Mark F. Bear","orcid":"0000-0002-9903-2541","position":3,"is_corresponding":false},{"id":275418,"name":"Richard L. Huganir","orcid":"0000-0001-9783-5183","position":4,"is_corresponding":false},{"id":465468,"name":"Jason D. Shepherd","orcid":"0000-0001-7384-8289","position":5,"is_corresponding":false},{"id":569152,"name":"Madeleine Kyrke‐Smith","orcid":"0000-0001-7736-3131","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:07.789881Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}