{"doi":"10.1101/2019.12.31.891317","title":"Identification of human CD4 <sup>+</sup> T cell populations with distinct antitumor activity","abstract":"Abstract How naturally arising human CD4 + T helper subsets impact tumor immunity is unknown. We reported that human CD4 + CD26 high T cells elicit potent immunity against solid tumor malignancies. As CD26 high T cells secrete type-17 cytokines and have been categorized as Th17 cells, we posited these helper populations would possess similar molecular properties. Herein, we reveal that CD26 high T cells are epigenetically and transcriptionally distinct from Th17 cells. Of clinical significance, CD26 high T cells engineered with a chimeric antigen receptor (CAR) ablated large human tumors to a greater extent than enriched Th17, Th1, or Th2 cells. Moreover, CD26 high T cells mediated curative responses in mice, even when redirected with a suboptimal CAR and without the aid of CD8 + CAR T cells. CD26 high T cells co-secreted effector cytokines at heightened levels and robustly persisted. Collectively, our work reveals the potential of human CD4 + T cell populations to improve durability of solid tumor therapies.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2020,"id":126117,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314034,"name":"Hannah M. Knochelmann","orcid":"0000-0003-0644-123X","position":1,"is_corresponding":false},{"id":12713,"name":"Stefanie R. Bailey","orcid":"0000-0002-1175-521X","position":2,"is_corresponding":false},{"id":574146,"name":"Logan W. Huff","orcid":null,"position":3,"is_corresponding":false},{"id":478704,"name":"Jacob S. Bowers","orcid":"0000-0003-2589-2351","position":4,"is_corresponding":false},{"id":573525,"name":"Kinga Majchrzak","orcid":"0000-0002-9504-4588","position":5,"is_corresponding":false},{"id":314036,"name":"Megan M. Wyatt","orcid":"0000-0003-1316-260X","position":6,"is_corresponding":false},{"id":314037,"name":"Mark P. Rubinstein","orcid":"0000-0003-4748-0286","position":7,"is_corresponding":false},{"id":242937,"name":"Shikhar Mehrotra","orcid":"0000-0002-5411-9504","position":8,"is_corresponding":false},{"id":373463,"name":"Michael I. Nishimura","orcid":"0009-0008-2288-6021","position":9,"is_corresponding":false},{"id":479929,"name":"Kent Armeson","orcid":null,"position":10,"is_corresponding":false},{"id":574147,"name":"Paul G. Giresi","orcid":null,"position":11,"is_corresponding":false},{"id":573526,"name":"Michael J. Zilliox","orcid":"0000-0001-7381-8397","position":12,"is_corresponding":false},{"id":326018,"name":"Hal E. Broxmeyer","orcid":"0000-0001-6575-0476","position":13,"is_corresponding":false},{"id":314041,"name":"Chrystal M. Paulos","orcid":"0000-0002-0784-2601","position":14,"is_corresponding":false},{"id":321623,"name":"Michelle H. Nelson","orcid":"0000-0001-7597-0923","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:23.509897Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}