{"doi":"10.1101/117523","title":"deStruct: Accurate Rearrangement Detection using Breakpoint Specific Realignment","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>We propose that a breakpoint specific alignment procedure would improve breakpoint prediction. Our method, deStruct, uses multiple stages of realignment and clustering to progressively refine breakpoint prediction quality and accuracy. We show using simulated data that deStruct predicts breakpoints with higher sensitivity and specificity than existing breakpoint prediction tools.</jats:p>","journal":null,"year":null,"id":611283,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1573125,"name":"Sohrab Shah","orcid":null,"position":1,"is_corresponding":false},{"id":1573126,"name":"S. Cenk Sahinalp","orcid":null,"position":2,"is_corresponding":false},{"id":22233,"name":"Andrew McPherson","orcid":"0000-0002-5654-5101","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"deStruct: Accurate Rearrangement Detection using Breakpoint Specific Realignment","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>We propose that a breakpoint specific alignment procedure would improve breakpoint prediction. Our method, deStruct, uses multiple stages of realignment and clustering to progressively refine breakpoint prediction quality and accuracy. We show using simulated data that deStruct predicts breakpoints with higher sensitivity and specificity than existing breakpoint prediction tools.</jats:p>","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W2606481030","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2017/03/18/117523.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2017/03/18/117523.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/117523","host_type":"publisher"},{"url":"https://doi.org/10.1101/117523","host_type":"repository"}],"fields_of_study":["Genomics and Phylogenetic Studies","Genomics and Chromatin Dynamics","Molecular Biology Techniques and Applications"],"mesh_terms":[],"keywords":["Breakpoint","Computer science","Cluster analysis","Data mining","Algorithm","Artificial intelligence","Biology","Genetics","Chromosomal translocation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T17:49:50.471170Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}