{"doi":"10.1101/109298","title":"Can the location of a trophectoderm biopsy contribute to human blastocyst development ?","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>The influence of the location of a trophectoderm biopsy in human blastocysts on the development of those blastocysts has not yet been investigated. In our prospective study (n=92), our multivariate logistic regression analysis indicated that blastocoel development was influenced by the location of the trophectoderm biopsy (p=0.049) and by the type of human blastocyst used (fresh or thawed) (p=0.037), regardless of the patient’s age (p=0.507) and the number of days for the human blastocyst in the pretrophectoderm biopsy (p=0.239). Therefore, when a trophectoderm biopsy is close to the inner cell mass (ICM) in human blastocysts, it improves the progress of blastocoel development.</jats:p>\n                <jats:p>Clinical evidence suggests that the progress of blastocoel development is a predictor of clinical outcomes after single blastocyst transfer. Therefore, when the trophectoderm biopsy is done from near the ICM, improvement of clinical outcomes after single blastocyst transfer may be expected.</jats:p>","journal":null,"year":null,"id":687577,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1796286,"name":"Miyako Funabiki","orcid":null,"position":1,"is_corresponding":false},{"id":1796287,"name":"Sagiri Taguchi","orcid":null,"position":2,"is_corresponding":false},{"id":1796290,"name":"Fumie Saji","orcid":null,"position":3,"is_corresponding":false},{"id":1796294,"name":"Namiko Amano","orcid":null,"position":4,"is_corresponding":false},{"id":1796296,"name":"Kate Young Louise","orcid":null,"position":5,"is_corresponding":false},{"id":1215817,"name":"Yoshitaka Nakamura","orcid":"0000-0001-9857-0754","position":6,"is_corresponding":false},{"id":1796285,"name":"Tomoe Takano","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Can the location of a trophectoderm biopsy contribute to human blastocyst development ?","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>The influence of the location of a trophectoderm biopsy in human blastocysts on the development of those blastocysts has not yet been investigated. In our prospective study (n=92), our multivariate logistic regression analysis indicated that blastocoel development was influenced by the location of the trophectoderm biopsy (p=0.049) and by the type of human blastocyst used (fresh or thawed) (p=0.037), regardless of the patient’s age (p=0.507) and the number of days for the human blastocyst in the pretrophectoderm biopsy (p=0.239). Therefore, when a trophectoderm biopsy is close to the inner cell mass (ICM) in human blastocysts, it improves the progress of blastocoel development.</jats:p>\n                <jats:p>Clinical evidence suggests that the progress of blastocoel development is a predictor of clinical outcomes after single blastocyst transfer. Therefore, when the trophectoderm biopsy is done from near the ICM, improvement of clinical outcomes after single blastocyst transfer may be expected.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W2604374113","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2017/02/20/109298.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2017/02/20/109298.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/109298","host_type":"publisher"},{"url":"https://doi.org/10.1101/109298","host_type":"repository"}],"fields_of_study":["Prenatal Screening and Diagnostics","Reproductive Biology and Fertility","Renal and related cancers"],"mesh_terms":[],"keywords":["Blastocoel","Blastocyst","Inner cell mass","Blastocyst Transfer","Biopsy","Andrology","Biology","Embryogenesis","Embryo","Medicine","Pathology","Cell biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T22:16:27.753024Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}