{"doi":"10.1101/105890","title":"Cocaine place conditioning strengthens location-specific hippocampal inputs to the nucleus accumbens","abstract":"<jats:p>Conditioned place preference (CPP) is a widely used model of addiction-related behavior whose underlying mechanism is not understood. In this study, we used dual site silicon probe recordings in freely moving mice to examine interactions between the hippocampus and nucleus accumbens in cocaine CPP. We found that CPP was associated with recruitment of nucleus accumbens medium spiny neurons to fire in the cocaine-paired location, and this recruitment was driven predominantly by selective strengthening of hippocampal inputs arising from place cells that encode the cocaine-paired location. These findings provide in vivo evidence that the synaptic potentiation in the accumbens caused by repeated cocaine administration preferentially affects inputs that were active at the time of drug exposure. This provides a potential physiological mechanism by which drug use becomes associated with specific environmental contexts.</jats:p>","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":null,"id":26042,"datarank":0.35396496006753286,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.1125492732024178,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.1125492732024178,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":151658,"name":"Adrien Peyrache","orcid":null,"position":1,"is_corresponding":false},{"id":151659,"name":"Andrea Cumpelik","orcid":null,"position":2,"is_corresponding":false},{"id":151660,"name":"Daniela Cassataro","orcid":null,"position":3,"is_corresponding":false},{"id":151661,"name":"György Buzsáki","orcid":null,"position":4,"is_corresponding":false},{"id":151657,"name":"Lucas Sjulson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18998881","pmcid":null,"openalex_id":"https://openalex.org/W2587651958","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"5K08DA036657-03","title":"Accumbens neuronal subtypes in addiction"},{"funder_name":"National Institutes of Health","grant_id":"5R01MH107396-04","title":"Brain rhythms-assisted memory enhancement"}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2017/05/12/105890.full.pdf","host_type":"repository"},{"url":"https://doi.org/10.1016/j.neuron.2018.04.015","host_type":"GREEN"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2017/05/12/105890.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/105890","host_type":"publisher"},{"url":"https://doi.org/10.1101/105890","host_type":"repository"},{"url":"http://www.cell.com/article/S0896627318303234/pdf","host_type":""},{"url":"https://dx.doi.org/10.1101/105890","host_type":""},{"url":"http://dx.doi.org/10.1101/105890","host_type":""}],"fields_of_study":["Memory and Neural Mechanisms","Neuroscience and Neuropharmacology Research","Sleep and Wakefulness Research","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Nucleus accumbens","Conditioned place preference","Neuroscience","Hippocampal formation","Long-term potentiation","Addiction","Conditioning","Mechanism (biology)","Hippocampus","Medium spiny neuron","Reinforcement","Psychology","Basal ganglia","Central nervous system","Medicine","Physics","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T10:48:02.599416Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}