{"doi":"10.1101/073510","title":"Retroviral origins of the\n                  <i>Caenorhabditis elegans</i>\n                  orphan gene F58H7.5","abstract":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  This work describes the results of the genome-scale analysis of endogenous retrovirus insertions in two\n                  <jats:italic>C. elegans</jats:italic>\n                  isolates: the prototype N2 (Bristol) and CB4856 (Hawaii). In total thirteen, identification of potentially replication competent, endogenous retroviral elements is described. Ten elements were identified as conserved between N2 and CB4856 by the reciprocal match of paired LTRs. The description focuses on the particular endogenous retrovirus insertion wich is identified on the proximal arm of the chromosome IV (located at positions IV: 912,948 – 921,658 and IV: 899,767 – 908,485 of the N2 and CB4856 respectively). In both isolates the inserted provirus is flanked by the predicted long terminal repeats (LTR)s of the length of 415 bp and of identical sequence. Provided the absolute LTR sequence identity this particular provirus represents insertion acquired prior to split from the common ancestor, suggesting this insertion event is evolutionary recent. The identified insertion of the endogenous retrovirus embeds the orphan gene F58H7.5, specific to\n                  <jats:italic>C. elegans</jats:italic>\n                  lineage. This unprecedented example establishes that in the evolutionary past\n                  <jats:italic>C. elegans</jats:italic>\n                  , had acquired the gene of the retroviral origins presumably via mechanisms involving the RNA intermediate.\n                </jats:p>\n                <jats:sec>\n                  <jats:title>Importance</jats:title>\n                  <jats:p>\n                    This work describes the retroviral origins of\n                    <jats:italic>C. elegans</jats:italic>\n                    orphan gene F58H7.5. Presented work implies that in the evolutionary past the\n                    <jats:italic>C. elegans</jats:italic>\n                    have acquired new gene as a result of the infection event.\n                    <jats:italic>C. elegans</jats:italic>\n                    is presently regarded as genetic model organism widely used in genetic research. The genome of\n                    <jats:italic>C. elegans</jats:italic>\n                    have been sequenced nearly 20 years ago. This unprecedented example establishes that in the evolutionary past C. elegans genome, had acquired the gene of the retroviral origins presumably via mechanisms involving the RNA intermediate.\n                  </jats:p>\n                </jats:sec>","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":null,"id":40857,"datarank":0.28987779143444703,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.04846210456933192,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.04846210456933192,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":197758,"name":"Wadim J Kapulkin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18998881","pmcid":null,"openalex_id":"https://openalex.org/W2512839034","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2016/12/17/073510.full.pdf","host_type":"repository"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2016/12/17/073510.full.pdf","host_type":"GREEN"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2016/12/17/073510.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/073510","host_type":"publisher"},{"url":"https://doi.org/10.1101/073510","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","CRISPR and Genetic Engineering","Evolution and Genetic Dynamics","Biology"],"mesh_terms":[],"keywords":["Provirus","Endogenous retrovirus","Caenorhabditis elegans","Biology","Genetics","Gene","Retrovirus","Genome","Long terminal repeat","Transposable element","Caenorhabditis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T17:39:42.254061Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}