{"doi":"10.1099/vir.0.18881-0","title":"Characterization of a neurovirulent aciclovir-resistant variant of herpes simplex virus","abstract":null,"journal":"Journal of General Virology","year":2003,"id":620414,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1601600,"name":"Mike Sowa","orcid":null,"position":1,"is_corresponding":false},{"id":868165,"name":"Peter Collins","orcid":null,"position":2,"is_corresponding":false},{"id":1601601,"name":"Rob J. 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Using a sensitive assay, it has been demonstrated that preparations of this virus are able to induce low but consistent levels of thymidine kinase (TK) activity. However, this activity results from a high frequency mutational event that inserts a further G into the 'G-string' motif and thus restores the TK open reading frame. Passage of this virus through the nervous system of mice results in the rapid selection of the TK-positive variant. Thus, this variant is the major component in virus reactivated from latently infected ganglia. Mutation frequency appears to be influenced by the genetic background of the virus.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12771407","pmcid":null,"openalex_id":"https://openalex.org/W2102565620","authors":[],"funders":[],"total_grants":0,"fwci":0.8052,"citation_percentile":0.75238907,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2017,"count":2},{"year":2021,"count":2},{"year":2023,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18881-0?crawler=true","host_type":"publisher"},{"url":"https://doi.org/10.1099/vir.0.18881-0","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12771407","host_type":"repository"}],"fields_of_study":["Herpesvirus Infections and Treatments","Toxin Mechanisms and Immunotoxins","Acne and Rosacea Treatments and Effects","Acyclovir","Amino Acid Sequence","Animals","Antiviral Agents","Base Sequence","Cell Line","Chlorocebus aethiops","Cricetinae","DNA, Viral","Drug Resistance, Viral","Frameshift Mutation","Ganglia, Sensory","Genetic Variation","Genotype","Herpes Simplex","Herpesvirus 1, Human","Humans","Mutation","Open Reading Frames","Phenotype","Protein Biosynthesis","Thymidine Kinase","Vero Cells","Virulence"],"mesh_terms":["Acyclovir","Amino Acid Sequence","Animals","Antiviral Agents","Base Sequence","Cell Line","Chlorocebus aethiops","DNA, Viral","Genotype","Cricetinae","Herpes Simplex","Humans","Mutation","Phenotype","Thymidine Kinase","Protein Biosynthesis","Genetic Variation","Vero Cells","Virulence","Open Reading Frames","Frameshift Mutation","Ganglia, Sensory","Herpesvirus 1, Human","Drug Resistance, Viral"],"keywords":["Virology","Herpes simplex virus","Biology","Virus","Aciclovir","Thymidine kinase","Mutation","Open reading frame","Alphaherpesvirinae","Resistance mutation","Serial passage","Herpesviridae","Gene","Reverse transcriptase","Polymerase chain reaction","Genetics","Viral disease","Peptide sequence"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Quality Education"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T10:59:34.720988Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}