{"doi":"10.1099/mic.0.001126","title":"The genetic basis of phage susceptibility, cross-resistance and host-range in Salmonella","abstract":"Though bacteriophages (phages) are known to play a crucial role in bacterial fitness and virulence, our knowledge about the genetic basis of their interaction, cross-resistance and host-range is sparse. Here, we employed genome-wide screens in Salmonella enterica serovar Typhimurium to discover host determinants involved in resistance to eleven diverse lytic phages including four new phages isolated from a therapeutic phage cocktail. We uncovered 301 diverse host factors essential in phage infection, many of which are shared between multiple phages demonstrating potential cross-resistance mechanisms. We validate many of these novel findings and uncover the intricate interplay between RpoS, the virulence-associated general stress response sigma factor and RpoN, the nitrogen starvation sigma factor in phage cross-resistance. Finally, the infectivity pattern of eleven phages across a panel of 23 genome sequenced Salmonella strains indicates that additional constraints and interactions beyond the host factors uncovered here define the phage host range.","journal":"Microbiology","year":2021,"id":154976,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":557807,"name":"Alexey E. Kazakov","orcid":"0000-0001-7245-857X","position":1,"is_corresponding":false},{"id":558017,"name":"Crystal Zhong","orcid":null,"position":2,"is_corresponding":false},{"id":559071,"name":"Hualan Liu","orcid":"0000-0002-9636-3855","position":3,"is_corresponding":false},{"id":301688,"name":"Elizabeth Kutter","orcid":"0000-0002-2775-684X","position":4,"is_corresponding":false},{"id":228809,"name":"Lauren Michelle Lui","orcid":"0000-0001-8720-5268","position":5,"is_corresponding":false},{"id":559072,"name":"Torben Nielsen","orcid":"0000-0002-0987-7189","position":6,"is_corresponding":false},{"id":559871,"name":"Héloïse Carion","orcid":null,"position":7,"is_corresponding":false},{"id":336360,"name":"Adam M. Deutschbauer","orcid":"0000-0003-2728-7622","position":8,"is_corresponding":false},{"id":556963,"name":"Vivek K. Mutalik","orcid":"0000-0001-7934-0400","position":9,"is_corresponding":false},{"id":2171,"name":"Adam P. Arkin","orcid":"0000-0002-4999-2931","position":10,"is_corresponding":false},{"id":556964,"name":"Benjamin A. Adler","orcid":"0000-0002-7488-3040","position":0,"is_corresponding":true}],"reference_count":159,"raw_metadata":null,"created_at":"2026-07-18T23:43:59.154159Z","pmid":"34910616","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}