{"doi":"10.1099/mic.0.000140","title":"Complex autoregulation of the post-transcriptional regulator RsmA in Pseudomonas aeruginosa","abstract":null,"journal":"Microbiology","year":2015,"id":649034,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1691722,"name":"Jonathan Perreault","orcid":null,"position":1,"is_corresponding":false},{"id":1691724,"name":"Eric Déziel","orcid":null,"position":2,"is_corresponding":false},{"id":573897,"name":"Fabrice Jean-Pierre","orcid":"0000-0002-3056-8356","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Complex autoregulation of the post-transcriptional regulator RsmA in Pseudomonas aeruginosa","abstract":"RsmA is a post-transcriptional RNA-binding protein that acts as a pleiotropic global regulator of mRNAs in the opportunistic pathogen Pseudomonas aeruginosa. Upon binding to its target, RsmA impedes the translation of the mRNA by the ribosome. The RsmA regulon affects over 500 genes, many of which have been identified as important in the pathogenicity of P. aeruginosa. Whilst the regulatory function of RsmA is relatively well characterized, the genetic regulation of rsmA itself at the transcriptional and translational levels remains poorly understood. Here, we show that RsmA is capable of self-regulation through an unorthodox mechanism. This regulation occurs via direct interaction of the protein with an RsmA-binding site located in the early portion of its coding sequence. To the best of our knowledge this is the first report of such an unusual regulation in pseudomonads.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26297258","pmcid":null,"openalex_id":"https://openalex.org/W1939730235","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"MOP-97888","title":null}],"total_grants":1,"fwci":1.3529,"citation_percentile":0.82287807,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2020,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000140?crawler=true","host_type":"publisher"},{"url":"https://doi.org/10.1099/mic.0.000140","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26297258","host_type":"repository"},{"url":"https://riip.hal.science/pasteur-01351203","host_type":"repository"}],"fields_of_study":["Bacterial Genetics and Biotechnology","RNA and protein synthesis mechanisms","Bacterial biofilms and quorum sensing","Bacterial Proteins","Base Sequence","Binding Sites","Gene Expression Regulation, Bacterial","Molecular Sequence Data","Nucleic Acid Conformation","Protein Binding","Pseudomonas aeruginosa","RNA Processing, Post-Transcriptional","RNA, Messenger","Transcription Factors","Transcription Initiation Site"],"mesh_terms":["Bacterial Proteins","Base Sequence","Binding Sites","Molecular Sequence Data","Nucleic Acid Conformation","Protein Binding","Pseudomonas aeruginosa","RNA Processing, Post-Transcriptional","RNA, Messenger","Transcription Factors","Gene Expression Regulation, Bacterial","Transcription Initiation Site"],"keywords":["Regulon","Pseudomonas aeruginosa","Biology","Transcriptional regulation","Translation (biology)","Regulator","Cell biology","Regulation of gene expression","Gene","Post-transcriptional regulation","Translational regulation","Ribosomal binding site","RNA-binding protein","Ribosome","Function (biology)","Genetics","RNA","Messenger RNA","Gene expression","Bacteria"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T03:14:17.741444Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}