{"doi":"10.1099/mgen.0.000395","title":"Epidemiological and molecular characterization of a novel adenovirus of squirrel monkeys after fatal infection during immunosuppression","abstract":"Adenoviruses are a frequent cause of acute upper respiratory tract infections that can also cause disseminated disease in immunosuppressed patients. We identified a novel adenovirus, squirrel monkey adenovirus 1 (SqMAdV-1), as the cause of fatal infection in an immunocompromised squirrel monkey ( Saimiri boliviensis ) at the Keeling Center for Comparative Medicine and Research (KCCMR). Sequencing of SqMAdV-1 revealed that it is most closely related (80.4 % pairwise nucleotide identity) to the titi monkey ( Plecturocebus cupreus ) adenovirus (TMAdV). Although identified in the titi monkey, TMAdV is highly lethal in these monkeys, and they are not thought to be the natural host. While SqMAdV-1 is similar to other primate adenoviruses in size and genomic characteristics, a nucleotide polymorphism at the expected stop codon of the DNA polymerase gene results in a 126 amino acid extension at the carboxy terminus, a feature not previously observed among other primate adenoviruses. PCR testing and partial sequencing of 95 archived faecal samples from other squirrel monkeys ( Saimiri boliviensis and Saimiri sciureus ) housed at the KCCMR revealed the presence of three distinct, and apparently endemic species of adenoviruses. A grouping of ten squirrel monkey adenovirus variants has high similarity to SqMAdV-1. A single adenovirus variant (designated SqMAdV-3), detected in five monkeys, has similarity to tufted capuchin ( Sapajus apella ) adenoviruses. The largest group of adenovirus variants detected (designated SqMAdV-2.0–2.16) has very high similarity (93–99 %) to the TMAdV, suggesting that squirrel monkeys may be the natural host of the TMAdV.","journal":"Microbial Genomics","year":2020,"id":111137,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":528263,"name":"Julio C. Ruiz","orcid":"0000-0001-5225-4537","position":1,"is_corresponding":false},{"id":455901,"name":"Wallace B. Baze","orcid":null,"position":2,"is_corresponding":false},{"id":529112,"name":"Gloria B. McClure","orcid":null,"position":3,"is_corresponding":false},{"id":528264,"name":"Carolyn L. Smith","orcid":"0000-0001-6603-0753","position":4,"is_corresponding":false},{"id":529113,"name":"Ricky Urbanowski","orcid":null,"position":5,"is_corresponding":false},{"id":529114,"name":"T. Boston","orcid":null,"position":6,"is_corresponding":false},{"id":418554,"name":"Joe H. Simmons","orcid":"0000-0003-1815-6831","position":7,"is_corresponding":false},{"id":405041,"name":"Lawrence E. Williams","orcid":"0000-0003-2267-9918","position":8,"is_corresponding":false},{"id":418555,"name":"Christian R. Abee","orcid":"0000-0002-5459-3732","position":9,"is_corresponding":false},{"id":301633,"name":"John A. Vanchiere","orcid":"0000-0001-6863-4323","position":10,"is_corresponding":false},{"id":528262,"name":"Donna Rogers","orcid":"0000-0002-3879-5684","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T23:13:05.597252Z","pmid":"32614763","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}