{"doi":"10.1099/jmm.0.000514","title":"Performance of point-of-care Xpert HIV-1 plasma viral load assay at a tertiary HIV care centre in Southern India","abstract":null,"journal":"Journal of Medical Microbiology","year":2017,"id":596929,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340122,"name":"Ramachandran Vignesh","orcid":"0000-0001-5805-9169","position":1,"is_corresponding":false},{"id":1466184,"name":"Jayaseelan Boobalan","orcid":"0000-0002-1322-317X","position":2,"is_corresponding":false},{"id":1528977,"name":"Sunil Suhas Solomon","orcid":null,"position":3,"is_corresponding":false},{"id":432912,"name":"Shanmugam Saravanan","orcid":"0000-0002-5991-8022","position":4,"is_corresponding":false},{"id":432913,"name":"Pachamuthu Balakrishnan","orcid":"0000-0002-1710-9155","position":5,"is_corresponding":false},{"id":1528976,"name":"Chinnambedu Ravichandran Swathirajan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Performance of point-of-care Xpert HIV-1 plasma viral load assay at a tertiary HIV care centre in Southern India","abstract":"Background. Sustainable suppression of HIV replication forms the basis of anti-retroviral therapy (ART) medication. Thus, reliable quantification of HIV viral load has become an essential factor to monitor the effectiveness of the ART. Longer turnaround-time (TAT), batch testing and technical skills are major drawbacks of standard real-time PCR assays. Methods. The performance of the point-of-care Xpert HIV-1 viral load assay was evaluated against the Abbott RealTime PCR m2000rt system. A total of 96 plasma specimens ranging from 2.5 log10 copies ml−1 to 4.99 log10 copies ml−1 and proficiency testing panel specimens were used. Precision and accuracy were checked using the Pearson correlation co-efficient test and Bland–Altman analysis. Results. Compared to the Abbott RealTime PCR, the Xpert HIV-1 viral load assay showed a good correlation (Pearson r=0.81; P<0.0001) with a mean difference of 0.27 log10 copies ml−1 (95 % CI, −0.41 to 0.96 log10 copies ml−1; sd, 0.35 log10 copies ml−1). Conclusion. Reliable and ease of testing individual specimens could make the Xpert HIV-1 viral load assay an efficient alternative method for ART monitoring in clinical management of HIV disease in resource-limited settings. The rapid test results (less than 2 h) could help in making an immediate clinical decision, which further strengthens patient care.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28901908","pmcid":null,"openalex_id":"https://openalex.org/W2755373778","authors":[],"funders":[],"total_grants":0,"fwci":1.2398,"citation_percentile":0.77992439,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":4},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":5}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000514?crawler=true","host_type":"publisher"},{"url":"https://doi.org/10.1099/jmm.0.000514","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28901908","host_type":"repository"}],"fields_of_study":["HIV/AIDS drug development and treatment","HIV Research and Treatment","HIV/AIDS Research and Interventions","Biomarkers","HIV Infections","HIV-1","Humans","India","Point-of-Care Systems","RNA, Viral","Reproducibility of Results","Sensitivity and Specificity","Viral Load"],"mesh_terms":["Humans","India","RNA, Viral","Sensitivity and Specificity","Reproducibility of Results","Biomarkers","HIV-1","HIV Infections","Point-of-Care Systems","Viral Load"],"keywords":["Viral load","Point of care","Turnaround time","Human immunodeficiency virus (HIV)","Medicine","Point-of-care testing","HIV diagnosis","Virology","Tertiary care","Antiretroviral therapy","Immunology","Internal medicine","Pathology","Computer science","HIV","Point-of-care","Xpert","Plasma Viral Load"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:44:28.633249Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}