{"doi":"10.1098/rstb.2014.0331","title":"What's in a genome? The C-value enigma and the evolution of eukaryotic genome content","abstract":"<jats:p>Some notable exceptions aside, eukaryotic genomes are distinguished from those of Bacteria and Archaea in a number of ways, including chromosome structure and number, repetitive DNA content, and the presence of introns in protein-coding regions. One of the most notable differences between eukaryotic and prokaryotic genomes is in size. Unlike their prokaryotic counterparts, eukaryotes exhibit enormous (more than 60 000-fold) variability in genome size which is not explained by differences in gene number. Genome size is known to correlate with cell size and division rate, and by extension with numerous organism-level traits such as metabolism, developmental rate or body size. Less well described are the relationships between genome size and other properties of the genome, such as gene content, transposable element content, base pair composition and related features. The rapid expansion of ‘complete’ genome sequencing projects has, for the first time, made it possible to examine these relationships across a wide range of eukaryotes in order to shed new light on the causes and correlates of genome size diversity. This study presents the results of phylogenetically informed comparisons of genome data for more than 500 species of eukaryotes. Several relationships are described between genome size and other genomic parameters, and some recommendations are presented for how these insights can be extended even more broadly in the future.</jats:p>","journal":"Philosophical Transactions of the Royal Society B: Biological Sciences","year":2015,"id":39844,"datarank":7.017990866225522,"base_score":5.808142489980444,"endowment":5.808142489980444,"self_citation_contribution":0.8712213734970667,"citation_network_contribution":6.146769492728455,"self_endowment_contribution":0.8712213734970667,"citer_contribution":6.146769492728455,"corpus_percentile":null,"corpus_rank":null,"citation_count":332,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":24,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":194731,"name":"T. 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