{"doi":"10.1098/rstb.2014.0212","title":"Illuminating neural circuits and behaviour in\n                    <i>Caenorhabditis elegans</i>\n                    with optogenetics","abstract":"<jats:p>\n                    The development of optogenetics, a family of methods for using light to control neural activity via light-sensitive proteins, has provided a powerful new set of tools for neurobiology. These techniques have been particularly fruitful for dissecting neural circuits and behaviour in the compact and transparent roundworm\n                    <jats:italic>Caenorhabditis elegans</jats:italic>\n                    . Researchers have used optogenetic reagents to manipulate numerous excitable cell types in the worm, from sensory neurons, to interneurons, to motor neurons and muscles. Here, we show how optogenetics applied to this transparent roundworm has contributed to our understanding of neural circuits.\n                  </jats:p>","journal":"Philosophical Transactions of the Royal Society B: Biological Sciences","year":2015,"id":30156,"datarank":1.707248960919121,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":1.1061489831342504,"self_endowment_contribution":0.6010999777848708,"citer_contribution":1.1061489831342504,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":48,"citers_with_citation_signal":37,"citers_with_endowment":37,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":164493,"name":"Mark J. Alkema","orcid":null,"position":1,"is_corresponding":false},{"id":164494,"name":"Aravinthan D. T. Samuel","orcid":null,"position":2,"is_corresponding":false},{"id":164492,"name":"Christopher Fang-Yen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26240427","pmcid":"PMC4528824","openalex_id":"https://openalex.org/W2180635444","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM084491","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM084491","title":null}],"total_grants":2,"fwci":2.3583,"citation_percentile":0.88312318,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":5},{"year":2018,"count":7},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":7},{"year":2022,"count":6},{"year":2023,"count":7},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://royalsociety.org/journals/ethics-policies/data-sharing-mining/","oa_locations":[{"url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2014.0212","host_type":"journal"},{"url":"https://europepmc.org/articles/pmc4528824?pdf=render","host_type":"GREEN"},{"url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2014.0212","host_type":"publisher"},{"url":"https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2014.0212","host_type":"publisher"},{"url":"https://doi.org/10.1098/rstb.2014.0212","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26240427","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4528824","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Circadian rhythm and melatonin","Photoreceptor and optogenetics research","Biology","Medicine","Engineering","Animals","Behavior, Animal","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Neural Pathways","Neurons","Opsins","Optogenetics","Signal Transduction"],"mesh_terms":["Animals","Behavior, Animal","Neural Pathways","Neurons","Signal Transduction","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Opsins","Optogenetics"],"keywords":["Optogenetics","Caenorhabditis elegans","Biological neural network","Neuroscience","Biology","Sensory system","Neuronal circuits","Neural activity","Nerve net","Neural Circuits"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T01:55:18.683418Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}