{"doi":"10.1097/yic.0b013e32832e5b0d","title":"Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients","abstract":null,"journal":"International Clinical Psychopharmacology","year":2009,"id":637938,"datarank":0.6476232170304466,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":0.0,"self_endowment_contribution":0.6476232170304466,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1656666,"name":"Raffaella Calati","orcid":null,"position":1,"is_corresponding":false},{"id":1656668,"name":"Isabelle Massat","orcid":null,"position":2,"is_corresponding":false},{"id":1656670,"name":"Sylvie Linotte","orcid":null,"position":3,"is_corresponding":false},{"id":351434,"name":"Siegfried Kasper","orcid":"0000-0002-9327-2843","position":4,"is_corresponding":false},{"id":1656672,"name":"Yves Lecrubier","orcid":null,"position":5,"is_corresponding":false},{"id":1656674,"name":"Roser Sens-Espel","orcid":null,"position":6,"is_corresponding":false},{"id":1656675,"name":"Joseph Bollen","orcid":null,"position":7,"is_corresponding":false},{"id":351436,"name":"Joseph Zohar","orcid":"0000-0002-6925-9104","position":8,"is_corresponding":false},{"id":1656677,"name":"Jacques Berlo","orcid":null,"position":9,"is_corresponding":false},{"id":1656679,"name":"Patricia Lienard","orcid":null,"position":10,"is_corresponding":false},{"id":650402,"name":"Diana De Ronchi","orcid":"0000-0002-2913-0621","position":11,"is_corresponding":false},{"id":351440,"name":"Julien Mendlewicz","orcid":"0000-0002-6131-2732","position":12,"is_corresponding":false},{"id":351437,"name":"Daniel Souery","orcid":"0000-0003-3434-5958","position":13,"is_corresponding":false},{"id":184617,"name":"Alessandro Serretti","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients","abstract":"Cytochrome P450 genes are involved in the metabolism of antidepressants and could influence treatment response. The aim of this study was to investigate the role of allelic variations of the cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes in antidepressant treatment response and remission rates. Two hundred and seventy-eight patients affected by major depression, responders (N = 81) and nonresponders (N=197) to at least one adequate antidepressant treatment, were recruited with a multicentre design for resistant depression and genotyped for all relevant variations. None of the considered metabolic profiles (e.g. poor, intermediate, extensive and ultrarapid metabolizers) was found to be associated with either response or remission rates. In conclusion, the investigated cytochrome genes do not seem to play a major role in antidepressant response in the present sample of depressive patients. Nevertheless, methodological and sample size limitations of this study do not allow definitive conclusions.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19593158","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":null,"oa_locations":[{"url":"https://journals.lww.com/10.1097/YIC.0b013e32832e5b0d","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","Aryl Hydrocarbon Hydroxylases","Cytochrome P-450 CYP1A2","Cytochrome P-450 CYP2D6","Antidepressive Agents","Genotype","Alleles","Adult","Aged","Aged, 80 and over","Middle Aged","Female","Male","Genetic Variation","Cytochrome P-450 CYP2C9","Cytochrome P-450 CYP2C19","Major Depressive Disorder"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T19:46:48.630876Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}