{"doi":"10.1097/qco.0b013e3282f486c9","title":"Epidermodysplasia verruciformis and human papilloma virus","abstract":null,"journal":"Current Opinion in Infectious Diseases","year":2008,"id":618232,"datarank":0.6846522287201755,"base_score":4.564348191467836,"endowment":4.564348191467836,"self_citation_contribution":0.6846522287201755,"citation_network_contribution":0.0,"self_endowment_contribution":0.6846522287201755,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":95,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1594745,"name":"Brenda Bartlett","orcid":null,"position":1,"is_corresponding":false},{"id":179267,"name":"Stephen Tyring","orcid":null,"position":2,"is_corresponding":false},{"id":1594744,"name":"Aron Gewirtzman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Epidermodysplasia verruciformis and human papilloma virus","abstract":"PURPOSE OF REVIEW: Despite its rarity, epidermodysplasia verruciformis was addressed in depth in recent literature. Patients are afflicted by persistent human papillomavirus infections and develop cutaneous malignancies more frequently and younger than in the general population. The disease is therefore considered a model for a viral role in cutaneous oncogenesis, although implication is controversial. We focus on recent findings in genetics, highlight multiple viewpoints regarding the role of epidermodysplasia verruciformis-human papillomavirus in nonmelanoma skin cancer and other diseases, and discuss treatment strategies. RECENT FINDINGS: Susceptibility loci for epidermodysplasia verruciformis were mapped and encoded protein functions are becoming better understood, but a unified genetic theory for epidermodysplasia verruciformis is lacking. Epidermodysplasia verruciformis-human papillomavirus, originally thought present only in epidermodysplasia verruciformis, is now considered ubiquitous, its role still being elucidated. Numerous therapies for epidermodysplasia verruciformis lesions were proposed, although there is no consensual first-line treatment strategy. SUMMARY: Discoveries of novel mutations and further study of epidermodysplasia verruciformis-human papillomavirus in lesional and nonlesional skin of epidermodysplasia verruciformis patients and the general population may generate a cohesive theory regarding a viral role in cutaneous oncogenesis. Future understanding of the disease may yield an optimal approach to treating epidermodysplasia verruciformis patients.","is_dataset_classified":null,"base_score":4.564348191467836,"endowment":4.564348191467836,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18317036","pmcid":null,"openalex_id":"https://openalex.org/W1995160583","authors":[],"funders":[],"total_grants":0,"fwci":5.9863,"citation_percentile":0.9655118,"influential_citations":0,"citation_trend":[{"year":2012,"count":9},{"year":2013,"count":4},{"year":2014,"count":8},{"year":2015,"count":3},{"year":2016,"count":6},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":3},{"year":2021,"count":5},{"year":2022,"count":1},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://journals.lww.com/10.1097/QCO.0b013e3282f486c9","host_type":"publisher"},{"url":"https://doi.org/10.1097/qco.0b013e3282f486c9","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18317036","host_type":"repository"}],"fields_of_study":["Cervical Cancer and HPV Research","Cancer-related Molecular Pathways","Cancer and Skin Lesions","Adjuvants, Immunologic","Alphapapillomavirus","Antiviral Agents","Epidermodysplasia Verruciformis","Genetic Predisposition to Disease","Humans","Papillomavirus Infections","Skin Neoplasms"],"mesh_terms":["Adjuvants, Immunologic","Antiviral Agents","Epidermodysplasia Verruciformis","Humans","Skin Neoplasms","Genetic Predisposition to Disease","Papillomavirus Infections","Alphapapillomavirus"],"keywords":["Epidermodysplasia verruciformis","Skin cancer","Population","Medicine","Dermatology","Cancer","Virology","Virus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:46:46.296460Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}