{"doi":"10.1097/qad.0b013e32836146cd","title":"HLA-A*68","abstract":null,"journal":"AIDS","year":2013,"id":619486,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342840,"name":"Anette Stryhn","orcid":"0000-0002-4581-3553","position":1,"is_corresponding":false},{"id":501925,"name":"Mikkel Harndahl","orcid":null,"position":2,"is_corresponding":false},{"id":292658,"name":"Jonathan M. Carlson","orcid":"0000-0001-6618-3653","position":3,"is_corresponding":false},{"id":1598676,"name":"Alasdair J. Leslie","orcid":null,"position":4,"is_corresponding":false},{"id":1055797,"name":"Fabian Chen","orcid":null,"position":5,"is_corresponding":false},{"id":1598677,"name":"Lynn Riddell","orcid":null,"position":6,"is_corresponding":false},{"id":412591,"name":"Joseph Mulenga","orcid":null,"position":7,"is_corresponding":false},{"id":108341,"name":"Bruce D. Walker","orcid":"0000-0001-6122-9245","position":8,"is_corresponding":false},{"id":252002,"name":"Thumbi Ndung’u","orcid":"0000-0003-2962-3992","position":9,"is_corresponding":false},{"id":56543,"name":"Søren Buus","orcid":"0000-0001-8363-1999","position":10,"is_corresponding":false},{"id":106110,"name":"Philip Goulder","orcid":"0000-0002-9842-4674","position":11,"is_corresponding":false},{"id":406978,"name":"Henrik N. Kløverpris","orcid":"0000-0002-2165-3313","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HLA-A*68","abstract":"BACKGROUND: Human leukocyte allele (HLA) class I polymorphism has the greatest impact of human genetic variation on viral load set point. A substantial part of this effect is due to the action of HLA-B and HLA-C alleles. With few exceptions the role of HLA-A molecules in immune control of HIV is unclear. METHODS: We here study HLA-A*68:02, one of the most highly prevalent HLA-A alleles in C-clade infected sub-Saharan African populations, and one that plays a prominent role in the HIV-specific CD8 T-cell responses made against the virus. RESULTS: We define eight epitopes restricted by this allele and propose the peptide binding motif for HLA-A*68:02. Although one of these epitopes almost exactly overlaps an HLA-B*57-restricted epitope in Gag linked with immune control of HIV, this HLA-A*68:02-restricted Gag-TA10 response imposed only weak selection pressure on the virus and was not associated with significantly lower viral setpoint. The only HLA-A*68:02-restricted responses imposing strong selection pressure on HIV were in the flanking regions of Pol-EA8 and Pol-EA11 and within the Vpr-EV10 epitope (P = 8 × 10). However, targeting of this latter epitope was associated with significantly higher viral loads (P = 0.003), suggesting lack of efficacy. CONCLUSION: This study is consistent with previous data showing that HLA-A-restricted Gag-specific responses can impose selection pressure on HIV. In the case of HLA-A*68:02 the Gag response is subdominant, and apparently has little impact in natural infection. However, these data suggest the potential for high frequency vaccine-induced Gag responses restricted by this allele to have significant antiviral efficacy in vaccine recipients.","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23525031","pmcid":"PMC6315297","openalex_id":"https://openalex.org/W2086088983","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI46995","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI046995","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":3,"fwci":0.7634,"citation_percentile":0.69983891,"influential_citations":1,"citation_trend":[{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6315297","host_type":"repository"},{"url":"https://doi.org/10.1097/qad.0b013e32836146cd","host_type":"BRONZE"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6315297","host_type":"repository"},{"url":"https://journals.lww.com/10.1097/QAD.0b013e32836146cd","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23525031","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6315297","host_type":"repository"},{"url":"https://curis.ku.dk/portal/da/publications/hlaa6802restricted-gagspecific-cytotoxic-t-lymphocyte-responses-can-drive-selection-pressure-on-hiv-but-are-subdominant-and-ineffective(f79db6c5-a497-4fa8-bd24-a0abe19ee66a).html","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/f79db6c5-a497-4fa8-bd24-a0abe19ee66a","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","Immune Cell Function and Interaction","T-cell and B-cell Immunology","Medicine","Biology"],"mesh_terms":["Epitopes","HIV","Humans","Selection, Genetic","T-Lymphocytes, Cytotoxic","HLA-A Antigens","Africa South of the Sahara","CD8-Positive T-Lymphocytes","Nuclear Pore Complex Proteins","gag Gene Products, Human Immunodeficiency Virus"],"keywords":["Human leukocyte antigen","Medicine","Immunology","Antigen"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T07:22:41.416810Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}