{"doi":"10.1097/qad.0000000000001767","title":"Systematic identification of correlates of HIV infection","abstract":"<h4>Objective</h4>Better identification of at-risk groups could benefit HIV-1 care programmes. We systematically identified HIV-1 risk factors in two nationally representative cohorts of women in the Demographic and Health Surveys.<h4>Methods</h4>We identified and replicated the association of 1415 social, economic, environmental, and behavioral factors with HIV-1 status. We used the 2007 and 2013-2014 surveys conducted among 5715 and 15 433 Zambian women, respectively (688 shared factors). We used false discovery rate criteria to identify factors that are strongly associated with HIV-1 in univariate and multivariate models of the entire population, as well as in subgroups stratified by wealth, residence, age, and past HIV-1 testing.<h4>Results</h4>In the univariate analysis, we identified 102 and 182 variables that are associated with HIV-1 in the two surveys, respectively (79 factors were associated in both). Factors that were associated with HIV-1 status in full-sample analyses and in subgroups include being formerly married (adjusted OR 2007, 2.8, P < 10(-16); 2013-2014 2.8, P < 10(-29)), widowhood (aOR 3.7, P < 10(-12); and 4.2, P < 10(-30)), genital ulcers within 12 months (aOR 2.4, P < 10(-5); and 2.2, P < 10(-6)), and having a woman head of the household (aOR 1.7, P < 10(-7); and 2.1, P < 10(-26), while owning a bicycle (aOR 0.6, P < 10(-6); and 0.6, P < 10(-8)) and currently breastfeeding (aOR 0.5, P < 10(-9); and 0.4, P < 10(-26)) were associated with decreased risk. Area under the curve for HIV-1 positivity was 0.76-0.82.<h4>Conclusion</h4>Our X-wide association study identifies under-recognized factors related to HIV-1 infection, including widowhood, breastfeeding, and gender of head of the household. These features could be used to improve HIV-1 identification programs.","journal":"AIDS","year":2018,"id":12746,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.2837,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2018-04-24","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":34866,"name":"Jay Bhattacharya","orcid":"0000-0003-3867-3174","position":1,"is_corresponding":false},{"id":11482,"name":"Eran Bendavid","orcid":"0000-0002-8364-4711","position":3,"is_corresponding":false},{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":4,"is_corresponding":false},{"id":833,"name":"Chirag J. Patel","orcid":"0000-0002-8756-8525","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}