{"doi":"10.1097/mpg.0b013e3181f8417f","title":"Gamma‐glutamyl Transferase Is Strongly Associated With Degree of Overweight and Sex","abstract":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:label/><jats:p>Gamma‐glutamyl transferase (GGT) is a marker for cardiovascular risk and an independent predictor of long‐term outcome in adults. Epidemiological data from pediatric cohorts are rare. We studied the association of GGT to body mass index as a standard deviation score, sex, and age in 68,415 children (age 11.7 ± 4.4 years; 48% boys; body mass index 27.2 ± 7.4 kg/m<jats:sup>2</jats:sup>; GGT measured in n = 23,955). GGT &gt;50 U/L is strongly associated with extreme obesity (odds ratio 27.13, 95% confidence interval 15.07–48.85) and male sex (odds ratio 2.60, 95% confidence interval 2.03–3.31). GGT seems to be of clinical relevance and may be marketable as a surrogate in risk profiling for children with obesity.</jats:p></jats:sec>","journal":"Journal of Pediatric Gastroenterology and Nutrition","year":2011,"id":602751,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546009,"name":"Michael Thamm","orcid":null,"position":1,"is_corresponding":false},{"id":216245,"name":"Wieland Kiess","orcid":null,"position":2,"is_corresponding":false},{"id":271409,"name":"Antje Körner","orcid":"0000-0001-6001-0356","position":3,"is_corresponding":false},{"id":311756,"name":"Thomas Reinehr","orcid":"0000-0002-4351-1834","position":4,"is_corresponding":false},{"id":607842,"name":"Heiko Krude","orcid":"0000-0002-1169-0348","position":5,"is_corresponding":false},{"id":1546013,"name":"Ulrike Hoffmeister","orcid":null,"position":6,"is_corresponding":false},{"id":1546015,"name":"Reinhard W Holl","orcid":null,"position":7,"is_corresponding":false},{"id":782463,"name":"Susanna Wiegand","orcid":"0000-0001-8341-9533","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gamma‐glutamyl Transferase Is Strongly Associated With Degree of Overweight and Sex","abstract":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:label/><jats:p>Gamma‐glutamyl transferase (GGT) is a marker for cardiovascular risk and an independent predictor of long‐term outcome in adults. Epidemiological data from pediatric cohorts are rare. We studied the association of GGT to body mass index as a standard deviation score, sex, and age in 68,415 children (age 11.7 ± 4.4 years; 48% boys; body mass index 27.2 ± 7.4 kg/m<jats:sup>2</jats:sup>; GGT measured in n = 23,955). GGT &gt;50 U/L is strongly associated with extreme obesity (odds ratio 27.13, 95% confidence interval 15.07–48.85) and male sex (odds ratio 2.60, 95% confidence interval 2.03–3.31). GGT seems to be of clinical relevance and may be marketable as a surrogate in risk profiling for children with obesity.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21407118","pmcid":null,"openalex_id":"https://openalex.org/W2312874961","authors":[],"funders":[],"total_grants":0,"fwci":1.3893,"citation_percentile":0.81486664,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":5},{"year":2014,"count":1},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1097/MPG.0b013e3181f8417f","host_type":"publisher"},{"url":"https://doi.org/10.1097/mpg.0b013e3181f8417f","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21407118","host_type":"repository"}],"fields_of_study":["Liver Disease Diagnosis and Treatment","Folate and B Vitamins Research","Diet, Metabolism, and Disease","Adolescent","Biomarkers","Body Mass Index","Cardiovascular Diseases","Child","Female","Humans","Male","Obesity, Morbid","Odds Ratio","Risk Factors","Sex Factors","gamma-Glutamyltransferase"],"mesh_terms":["Adolescent","Cardiovascular Diseases","Child","Female","gamma-Glutamyltransferase","Humans","Male","Obesity, Morbid","Risk Factors","Sex Factors","Biomarkers","Body Mass Index","Odds Ratio"],"keywords":["Medicine","Odds ratio","Confidence interval","Body mass index","Overweight","Obesity","Internal medicine","Gamma-glutamyltransferase","Epidemiology","Enzyme","Biology","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:14:01.678666Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}