{"doi":"10.1097/ico.0b013e3181cbfa13","title":"Clinical Experience With N-Butyl Cyanoacrylate Tissue Adhesive in Corneal Perforations Secondary to Herpetic Keratitis","abstract":null,"journal":"Cornea","year":2010,"id":625383,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417664,"name":"Vishal Jhanji","orcid":"0000-0002-4429-2004","position":1,"is_corresponding":false},{"id":1617302,"name":"Marios Constantinou","orcid":null,"position":2,"is_corresponding":false},{"id":1617304,"name":"Jacqueline Beltz","orcid":null,"position":3,"is_corresponding":false},{"id":1617306,"name":"Enrique O Graue-Hernandez","orcid":null,"position":4,"is_corresponding":false},{"id":1617307,"name":"Rasik B Vajpayee","orcid":null,"position":5,"is_corresponding":false},{"id":1617300,"name":"Sonia Moorthy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical Experience With N-Butyl Cyanoacrylate Tissue Adhesive in Corneal Perforations Secondary to Herpetic Keratitis","abstract":"PURPOSE: To evaluate the success of cyanoacrylate tissue adhesive in the management of corneal perforations associated with herpetic keratitis. METHODS: Case records of 46 patients with microbiologically proven herpetic keratitis associated with corneal perforations that were treated with corneal gluing were analyzed retrospectively in a tertiary care hospital. N-Butyl cyanoacrylate tissue adhesive and bandage contact lens were applied in addition to antiviral therapy. The main outcome measure was preservation of the structural integrity of the globe. RESULTS: Glue application could heal corneal perforations in only 17 eyes (37%). Therapeutic keratoplasty had to be performed in 26 eyes (57%) because of failure of the glue. Fourteen eyes (31%) required multiple applications of tissue adhesive, and 2 eyes had to be eviscerated. Location of perforation, additional anterior chamber intervention, and use of prophylactic acyclovir therapy had no statistically significant effect on the overall final outcome. CONCLUSION: Corneal perforations associated with herpetic keratitis may not heal with glue application alone, and corneal transplantation surgery may be required to maintain the ocular structural integrity.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20539218","pmcid":null,"openalex_id":"https://openalex.org/W2064655124","authors":[],"funders":[],"total_grants":0,"fwci":0.607,"citation_percentile":0.72779001,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":4},{"year":2022,"count":3},{"year":2023,"count":5},{"year":2024,"count":3},{"year":2025,"count":7},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://journals.lww.com/00003226-201009000-00002","host_type":"publisher"},{"url":"https://doi.org/10.1097/ico.0b013e3181cbfa13","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20539218","host_type":"repository"}],"fields_of_study":["Ocular Infections and Treatments","Intraocular Surgery and Lenses","Corneal Surgery and Treatments"],"mesh_terms":["Acyclovir","Adult","Aged","Aged, 80 and over","Antiviral Agents","Enbucrilate","Female","Humans","Male","Middle Aged","Retrospective Studies","Tissue Adhesives","Wound Healing","Keratitis, Herpetic","Treatment Outcome","Corneal Perforation"],"keywords":["Cyanoacrylate","Corneal perforation","Medicine","Keratitis","corneal ulcer","GLUE","Surgery","Contact lens","Perforation","Cornea","Ophthalmology","Corneal transplantation","Fungal keratitis","Adhesive"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T06:37:44.505905Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}