{"doi":"10.1096/fj.202000415r","title":"Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model","abstract":"Epoxyeicosatrienoic acids (EET) and related epoxy fatty acids (EpFA) are endogenous anti-inflammatory compounds, which are converted by the soluble epoxide hydrolase (sEH) to dihydroxylethersatrienoic acids (DHETs) with lessened biological effects. Inhibition of sEH is used as a strategy to increase EET levels leading to lower inflammation. Rheumatoid arthritis is a chronic autoimmune disease that leads to destruction of joint tissues. This pathogenesis involves a complex interplay between the immune system, and environmental factors. Here, we investigate the effects of inhibiting sEH with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) on a collagen-induced arthritis model. The treatment with TPPU ameliorates hyperalgesia, edema, and decreases the expression of important pro-inflammatory cytokines of Th1 and Th17 profiles, while increasing Treg cells. Considering the challenges to control RA, this study provides robust data supporting that inhibition of the sEH is a promising target to treat arthritis.","journal":"The FASEB Journal","year":2020,"id":91759,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459311,"name":"Juliana Trindade Clemente‐Napimoga","orcid":"0000-0003-1068-3039","position":1,"is_corresponding":false},{"id":459312,"name":"Henrique Ballassini Abdalla","orcid":"0000-0002-7517-2830","position":2,"is_corresponding":false},{"id":459313,"name":"Sergio Marcolino Rosa","orcid":"0000-0002-8501-4721","position":3,"is_corresponding":false},{"id":459314,"name":"Carlos Ueira‐Vieira","orcid":"0000-0002-8369-9069","position":4,"is_corresponding":false},{"id":291097,"name":"Christophe Morisseau","orcid":"0000-0002-5672-6631","position":5,"is_corresponding":false},{"id":459315,"name":"Waldiceu A. Verri","orcid":"0000-0003-2756-9283","position":6,"is_corresponding":false},{"id":459316,"name":"Victor Ângelo Martins Montalli","orcid":"0000-0002-1927-7718","position":7,"is_corresponding":false},{"id":242185,"name":"Bruce D. Hammock","orcid":"0000-0003-1408-8317","position":8,"is_corresponding":false},{"id":459317,"name":"Marcelo Henrique Napimoga","orcid":"0000-0003-4472-365X","position":9,"is_corresponding":false},{"id":459310,"name":"Carlos Antônio Trindade‐da‐Silva","orcid":"0000-0002-5669-4190","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T22:29:21.932251Z","pmid":"32400048","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}